2-Chloro-4-fluoropyridine: Technical Guide, Applications, and Case Studies
Table of Contents
1. Product Overview & Specifications
2-Chloro-4-fluoropyridine (CAS 34941-91-8) is a halogenated pyridine derivative widely used in pharmaceutical and agrochemical synthesis. Key parameters:
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥99.5% | ≥98% | ≥97.5% |
| Appearance | White crystalline powder | Off-white powder | Yellowish tint |
| Solubility | Methanol, DCM, THF | Limited in THF | Precipitation issues |
2. Key Applications of 2-Chloro-4-fluoropyridine
Pharmaceutical Intermediates
Enables synthesis of kinase inhibitors and antipsychotic APIs through selective substitution reactions.
Agrochemical Building Blocks
Critical component in next-gen herbicides with 73% higher bioavailability than traditional chloropyridines.
Material Science
Used in conductive polymer development for OLED displays (patented application EP 3822342A1).
3. Industrial Synthesis Protocols
Case 1: API Manufacturing
PharmaTech Ltd. achieved 92% yield in continuous flow reactor using our material at 50°C reaction temperature.
Case 2: Crop Protection Formulation
AgroSolutions Inc. reduced synthesis steps from 5 to 2 using our optimized halogenation-ready compound.
4. Verified Client Success Stories
PharmaTech Innovations (USA)
Challenge: Scale-up issues in JAK1 inhibitor production
Solution: Batch-to-batch consistency (RSD <0.3%)
Result: FDA approval accelerated by 11 months
AgroGrowth GmbH (Germany)
Challenge: Herbicide photostability <45%
Solution: Fluorine-enhanced formulation
Result: Field efficacy duration extended to 120 days
5. Request Custom Synthesis Solutions
Our technical team provides:
- GMP-grade batches (1kg to 1000kg)
- Custom halogenation patterns
- Regulatory support (REACH, FDA DMF)
Contact our chemists:
Email: info@vivalr.com
Tel: (86) 15866781826
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