2-Aminopyrimidine

Table of Contents

• Overview of 2-Aminopyrimidine
• Technical Specifications & Comparative Analysis
• Key Applications & Industrial Uses
• Real-World Case Studies
• Request a Quote or Sample

Overview of 2-Aminopyrimidine

Chemical Profile

2-Aminopyrimidine (CAS 109-12-6) is a heterocyclic aromatic amine with the molecular formula C₄H₅N₃. As a versatile building block in organic synthesis, it serves as a critical intermediate for pharmaceuticals, agrochemicals, and specialty chemicals.

Key Properties

Technical Specifications & Comparative Analysis

Competitive Benchmarking

Key Applications & Industrial Uses

Pharmaceutical Industry

As a core scaffold in drug discovery, 2-Aminopyrimidine derivatives are essential for:

• Kinase inhibitors (e.g., Imatinib analogs)
• Anticancer agents targeting EGFR and VEGFR
• Antiviral compounds against HIV and HCV

Agrochemical Development

Used in synthesis of:

• Fungicides for crop protection
• Herbicide intermediates
• Insect growth regulators

Material Science

• Ligands for catalytic systems
• Coordination polymers
• OLED precursor materials

Real-World Case Studies

Case Study 1: Anticancer Drug Development

Client: Top 10 Global Pharma Company
Challenge: Develop selective JAK2 inhibitor with improved bioavailability
Solution: Utilized 2-Aminopyrimidine core to create lead compound with IC₅₀ = 3.2 nM
Outcome: Successful Phase I clinical trial entry

Case Study 2: Next-Gen Fungicide Formulation

Client: European Agrochemical Leader
Challenge: Combat resistant fungal strains in cereals
Solution: Developed pyrimidine-based fungicide with 98% efficacy at 50 ppm
Outcome: Achieved EU regulatory approval in 18 months

Case Study 3: Specialty Chemical Production

Client: US-Based Chemical Manufacturer
Challenge: Scale up API intermediate synthesis
Solution: Optimized Buchwald-Hartwig amination using 2-Aminopyrimidine
Outcome: Increased yield from 62% to 89% at 500 kg batch scale

Request a Quote or Sample

Our GMP-certified facility offers:

• Batch-to-batch consistency (HPLC purity ≥98%)
• Custom synthesis from gram to ton scale
• Regulatory support (REACH, FDA DMF)

Contact our technical team:
Email: info@vivalr.com
Phone: (86) 15866781826

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