5-Bromonicotinoyl Chloride Technical Guide
Table of Contents
- Product Specifications & Comparative Analysis
- Industrial Applications & Functional Advantages
- Operational Protocols & Handling Procedures
- Application Case Studies
- Client Implementation Examples
- Technical Consultation & Procurement
1. Product Specifications & Comparative Analysis
| Parameter | 5-Bromonicotinoyl Chloride | Standard Nicotinoyl Chloride |
|---|---|---|
| CAS Number | 39620-02-5 | 1005-85-2 |
| Molecular Formula | C6H3NOClBr | C6H4NOCl |
| Molecular Weight | 220.45 g/mol | 141.55 g/mol |
| Reactivity | Enhanced electrophilicity | Standard reactivity |
2. Industrial Applications & Functional Advantages
This high-purity organobromine compound serves as critical intermediate in:
- Pharmaceutical synthesis (kinase inhibitor precursors)
- Agrochemical production (neonicotinoid derivatives)
- Ligand development for catalytic systems
- Functional material modification
3. Operational Protocols & Handling Procedures
Essential safety measures compliant with GB 11984-2024 standards:
- Storage: Maintain inert atmosphere at 2-8°C
- Handling: Use dry argon glove boxes
- Neutralization: 10% sodium bicarbonate solution
- PPE Requirements: Class C chemical-resistant suits
4. Application Case Studies
4.1 Anticancer Drug Intermediate Synthesis
Demonstrated 92% yield improvement in EGFR inhibitor synthesis through optimized acylation reactions.
4.2 Crop Protection Formulation
Developed weather-resistant insecticide with 40% longer field persistence compared to conventional products.
5. Client Implementation Examples
| Client | Application | Outcome |
|---|---|---|
| PharmaTech Solutions | BTK inhibitor production | Reduced synthesis steps from 8 to 5 |
| AgroShield International | Systemic insecticide development | 60% reduction in LC50 values |


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