1. Chemical Profile & Specifications

2. Key Applications

• Pharmaceutical Intermediate: Critical precursor in Parecoxib sodium production (COX-2 inhibitor)
• Organic Synthesis: Building block for functionalized isoxazole derivatives
• Research Reagent: Used in medicinal chemistry studies for anti-inflammatory drug development

3. Synthesis Methods

Route 1: Deoxybenzoin Oxime Cyclization

Reagents: Deoxybenzoin oxime + Acetic acid
Yield: 56%

Route 2: Parecoxib Intermediate Conversion

Reagents: QC-1530 (CAS 181696-73-1)
Yield: 69%

4. Industry Applications

Pharmaceutical Manufacturing

Used in multi-step synthesis of non-steroidal anti-inflammatory drugs (NSAIDs)

Fine Chemicals

Intermediate for specialty chemicals requiring isoxazole ring functionalization

5. Case Studies

Case 1: Anti-Inflammatory API Production

Client: Top 10 Global Pharma Company
Application: Scaled-up production of Parecoxib sodium (batch size: 500kg)
Result: 98.5% purity achieved with GMP compliance

Case 2: Academic Research

Client: University of California, San Francisco
Application: Development of novel COX-2 inhibitors
Result: Enabled synthesis of 12 structural analogs for biological testing