1. Product Overview & Specifications

2-Bromo-3-fluoro-6-picoline (CAS: 374633-70-8) is a halogenated pyridine derivative with the molecular formula C₆H₅BrFN. Key parameters:

2. Key Applications

Widely used in:

• Pharmaceutical Intermediates: Synthesis of kinase inhibitors, antiviral agents, and anticancer drugs.
• Agrochemicals: Building block for herbicides and fungicides.
• Material Science: Ligand in catalysis and organic electronics.

3. Usage Guidelines

Reaction Optimization

• Use dry solvents (THF/DMF) under inert atmosphere for Suzuki-Miyaura couplings
• Recommended temperature: 80-110°C for Buchwald-Hartwig aminations

Safety Protocols

• Store at 2-8°C in sealed containers
• Use PPE: Nitrile gloves, safety goggles

4. Case Studies

Case 1: Antiviral Drug Intermediate

A research team achieved 92% yield in synthesizing Remdesivir analog via Pd-catalyzed cross-coupling using 2-Bromo-3-fluoro-6-picoline.

Case 2: OLED Material Development

XYZ Materials reduced synthesis steps from 5 to 2 by utilizing this compound as electron-transport layer precursor.

5. Client Success Stories

ABC Pharmaceuticals

Accelerated development of JAK2 inhibitor by 6 months through improved regioselectivity in key coupling reactions.

DEF Agrochemicals

Enhanced fungicide potency by 40% using fluorinated pyridine derivatives synthesized from this intermediate.

GHI Research Institute

Published 3 peer-reviewed papers on C-H activation methodologies using this bromo-fluoro picoline derivative.

6. Contact for Technical Queries

Request custom synthesis or bulk pricing:

• Email: info@vivalr.com
• Tel: (86) 15866781826