2-Chloro-4-Methoxypyrimidine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2-Chloro-4-Methoxypyrimidine (CAS 17228-64-5) is a high-purity intermediate widely used in pharmaceutical and agrochemical synthesis. Key parameters:
| Parameter | Value |
|---|---|
| CAS Number | 17228-64-5 |
| Molecular Formula | C5H5ClN2O |
| Molecular Weight | 144.56 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥98.5% (HPLC) |
| Melting Point | 89-92°C |
| Storage | 2-8°C in airtight container |
Comparative Analysis
| Parameter | 2-Chloro-4-Methoxypyrimidine | 2-Chloro-4-Methylpyrimidine | 4-Methoxypyrimidine |
|---|---|---|---|
| Reactivity | High | Moderate | Low |
| Pharma Applications | Wide | Limited | Niche |
| Shelf Life | 24 months | 18 months | 12 months |
2. Applications of 2-Chloro-4-Methoxypyrimidine
Pharmaceutical Industry
Key uses in drug development:
- Intermediate for kinase inhibitors (e.g., EGFR inhibitors)
- Building block for antiviral agents
- Precursor in anticancer drug synthesis
Agrochemical Sector
- Herbicide intermediates
- Fungicide formulations
3. Usage Scenarios & Case Studies
Scenario 1: Anticancer Drug Synthesis
Process: 2-Chloro-4-Methoxypyrimidine → Suzuki coupling → Purification → Final API
Yield: 82-85% at pilot scale
Scenario 2: Agrochemical Intermediate
Used in 3-step synthesis of broad-spectrum fungicides, achieving 95% selectivity.
4. Client Success Stories
| Client | Industry | Application | Results |
|---|---|---|---|
| Top 10 Pharma Co. | Pharmaceutical | Third-gen EGFR inhibitor development | Reduced synthesis steps from 7 to 4 |
| AgroChem Ltd. | Agrochemical | Next-gen herbicide production | 20% cost reduction vs traditional methods |
5. Request a Quote
Contact our technical team for:
- Custom synthesis protocols
- Bulk pricing (50kg+ orders)
- Regulatory support documentation
info@vivalr.com | (86) 15866781826


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