3-Chloro-5-fluoropyridine: Comprehensive User Guide

1. Product Overview & Specification Comparison

3-Chloro-5-fluoropyridine (CAS 3746-68-3) is a halogenated pyridine derivative with molecular formula C₅H₂ClF₁N and molecular weight 131.53 g/mol. This white crystalline solid boasts ≥98% purity and requires storage at 2-8°C in inert conditions.

2. Key Applications & Industrial Uses

This versatile intermediate enables:

• Pharmaceutical Synthesis: Core building block for kinase inhibitors and CNS drugs
• Agrochemical Production: Key precursor for next-gen herbicides
• Material Science: Ligand in catalytic systems for polymerization

3. Usage Scenarios & Best Practices

Scenario 1: Suzuki-Miyaura Coupling

Recommended conditions:

• Pd(PPh₃)₄ (2 mol%)
• K₂CO₃ base in DME/H₂O (3:1)
• 70°C, 12h reaction time

4. Real-World Client Case Studies

Case 1: Top 10 Pharma Company (2023)

Challenge: Develop third-generation EGFR inhibitor
Solution: Used as coupling partner in final API step
Result: 92% yield improvement vs previous intermediates

Case 2: EU Agrochemical Leader (2022)

Challenge: Create low-toxicity fungicide
Solution: Central scaffold for molecular optimization
Result: Achieved EC₅₀ = 0.8 μM against Botrytis

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