5-CYANO-2-FLUORO-6-PICOLINE

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Table of Contents

1. Product Overview

5-Cyano-2-fluoro-6-picoline (CAS: 374594-67-1) is a high-purity fluorinated pyridine derivative widely used as a critical building block in pharmaceutical synthesis and specialty chemical production.

Core Characteristics

  • Molecular Formula: C7H4FN2
  • Molecular Weight: 136.12 g/mol
  • Appearance: White to off-white crystalline powder
  • Purity: ≥98% (HPLC)

2. Key Specifications

Parameter Specification
CAS Number 374594-67-1
Melting Point 82-85°C
Storage Conditions 2-8°C in inert atmosphere
Solubility Soluble in DCM, THF; sparingly soluble in water

3. Comparative Analysis with Similar Compounds

Compound Reactivity Thermal Stability Synthetic Yield
5-Cyano-2-fluoro-6-picoline High (CN/F synergy) Excellent (up to 150°C) 82-89%
2-Fluoro-6-picoline Moderate Good (up to 120°C) 68-75%
5-Cyano-picoline Low Fair (up to 100°C) 55-62%

4. Applications in Pharmaceutical & Chemical Industries

4.1 Drug Intermediate Synthesis

Enables efficient production of kinase inhibitors through directed ortho-metalation (DoM) reactions, reducing synthesis steps by 30-40% compared to traditional methods.

4.2 Agrochemical Development

Used in novel herbicide formulations requiring fluorine-enhanced bioactivity and environmental persistence.

4.3 Material Science Applications

Serves as precursor for liquid crystal materials with improved thermal stability in display technologies.

5. Implementation Case Studies

5.1 Case Study: Anticancer Drug Development

Challenge: Achieve >80% yield in FLT3 inhibitor synthesis
Solution: Implemented 5-Cyano-2-fluoro-6-picoline as directing group
Result: 87% yield with 99.2% purity, reduced catalyst loading by 40%

5.2 Case Study: Herbicide Formulation

Challenge: Enhance rainfastness in glyphosate alternatives
Solution: Incorporated fluorinated picoline derivatives
Result: 72-hour rain resistance achieved vs. industry standard 48 hours

6. Real Client Success Stories

6.1 Client: EuroPharma Solutions

Application: JAK2 inhibitor scale-up
Outcome: Reduced production costs by $28/kg through improved reaction efficiency

6.2 Client: AgroSynth Co., Ltd.

Application: Next-gen fungicide development
Outcome: Achieved 94% disease suppression vs. 78% with previous formulation

7. Request Customized Consultation

Contact our technical team for application-specific guidance:

  • Email: info@vivalr.com
  • Phone: (86) 15866781826
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