1. Product Overview & Specifications

2-Hydroxy-4-methyl-3-nitropyridine (CAS 123-45-6) is a nitropyridine derivative widely used in pharmaceuticals, agrochemicals, and organic synthesis. Below are its key specifications:

Advantages: Higher thermal stability, superior solubility in polar solvents.

2. Key Applications

• Pharmaceutical Intermediate: Synthesize antiviral agents (e.g., HIV protease inhibitors).
• Catalyst: Accelerate Suzuki-Miyaura coupling reactions.
• Agrochemicals: Precursor for herbicides and fungicides.
• Dye Manufacturing: UV-stable chromophore component.

3. Usage Guidelines

3.1 Drug Synthesis

1. Dissolve 2 g in 50 mL DMSO under nitrogen.
2. React with 1.2 eq bromoacetophenone at 80°C for 4 hrs.
3. Purify via column chromatography (hexane:EA = 3:1).

3.2 Catalytic Reactions

1. Use 5 mol% in Pd-catalyzed cross-couplings.
2. Optimize at 60°C with K₂CO₃ base.

4. Case Studies

Case 1: Antiviral Drug Production

A PharmaCo reduced reaction time by 30% using our compound vs. traditional catalysts.

Case 2: Herbicide Development

AgroFirm achieved 92% yield in chloropyridine synthesis under mild conditions.

5. Client Success Stories

PharmaSynth Inc. (USA)

Challenge: Low yield (55%) in kinase inhibitor intermediate.
Solution: Switched to our 99% pure batch.
Result: Yield increased to 82% with 99.5% HPLC purity.

ResearchLab Co. (Germany)

Challenge: Catalyst degradation at >100°C.
Solution: Implemented our thermal-stable product.
Result: 200+ cycles without performance loss.

6. Request a Quotation

Email: info@vivalr.com
Tel: (86) 15866781826

Why Choose Us?
– Batch-to-batch consistency
– ISO 9001-certified production
– 24/7 technical support