4,6-Dichloro-5-nitropyrimidine

1. Product Overview & Specifications

4,6-Dichloro-5-nitropyrimidine (CAS: 4316-93-2) is a high-purity heterocyclic compound widely used in pharmaceutical synthesis and organic chemistry. Key parameters include:

Comparative Analysis

2. Key Applications

Pharmaceutical Synthesis

• Anticancer Agents: Core building block for VEGFR inhibitors targeting angiogenesis.
• Antiplatelet Drugs: Intermediate in Ticagrelor production (CAS 145783-14-8 variant).
• Antiviral Compounds: Precursor in nucleotide analog development.

Material Science

• Electronic material precursor for OLED/LED components
• Ligand in catalytic systems for cross-coupling reactions

3. Usage Guidelines

Storage & Handling

• Store in sealed containers at 2–8°C under inert atmosphere
• Moisture-sensitive: Use anhydrous reaction conditions

Synthetic Protocol Example

Synthesis of Carbonylpteridine Derivatives:
1. Dissolve 5.00 g (25.9 mmol) in THF (50 mL) at −25°C.
2. Add DIPEA (10 mL, 51.8 mmol) followed by cyclopropylamine (1.50 g, 26.7 mmol).
3. Stir for 1 hr under TLC monitoring.
4. Purify via column chromatography (hexane/EA 3:1).

4. Case Studies

Case 1: VEGFR Inhibitor Development

A research team synthesized eight carbonylpteridine derivatives using 4,6-Dichloro-5-nitropyrimidine as the starting material. Compound TM3 showed 78% inhibition against HepG2 cells at 10 μM.

Case 2: Ticagrelor Intermediate Production

Pharmaceutical manufacturer achieved 92% yield in large-scale synthesis of 4,6-Dichloro-5-nitro-2-propylthiopyrimidine (CAS 145783-14-8) under optimized Buchwald-Hartwig conditions.

5. Client Success Stories

Client A: Specialty Chemical Producer

Integrated 4,6-Dichloro-5-nitropyrimidine into their API production line, reducing synthesis steps by 40% for a kinase inhibitor project.

Client B: University Research Lab

Developed novel fluorescent probes using modified pyrimidine derivatives, published in ACS Applied Materials & Interfaces (2024).

6. Contact for Custom Solutions

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