Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
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5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents
1. Product Overview & Specifications
4,6-Dichloro-5-nitropyrimidine (CAS: 4316-93-2) is a high-purity heterocyclic compound widely used in pharmaceutical synthesis and organic chemistry. Key parameters include:
| Parameter | Specification |
|---|---|
| Molecular Formula | C4H2Cl2N3O2 |
| Molecular Weight | 208.99 g/mol |
| Appearance | Pale yellow crystalline solid |
| Melting Point | 248–250°C |
| Purity | ≥98% (HPLC) |
| Packaging | 1g, 5g, 25g, 100g, 500g (customizable) |
Comparative Analysis
| Variant | CAS Number | Substituent | Application Focus |
|---|---|---|---|
| Base Compound | 4316-93-2 | - | Broad-spectrum intermediate |
| 2-Propylthio Derivative | 145783-14-8 | Propylthio group | Ticagrelor intermediate (antiplatelet drug) |
2. Key Applications
Pharmaceutical Synthesis
- Anticancer Agents: Core building block for VEGFR inhibitors targeting angiogenesis.
- Antiplatelet Drugs: Intermediate in Ticagrelor production (CAS 145783-14-8 variant).
- Antiviral Compounds: Precursor in nucleotide analog development.
Material Science
- Electronic material precursor for OLED/LED components
- Ligand in catalytic systems for cross-coupling reactions
3. Usage Guidelines
Storage & Handling
- Store in sealed containers at 2–8°C under inert atmosphere
- Moisture-sensitive: Use anhydrous reaction conditions
Synthetic Protocol Example
Synthesis of Carbonylpteridine Derivatives:
1. Dissolve 5.00 g (25.9 mmol) in THF (50 mL) at −25°C.
2. Add DIPEA (10 mL, 51.8 mmol) followed by cyclopropylamine (1.50 g, 26.7 mmol).
3. Stir for 1 hr under TLC monitoring.
4. Purify via column chromatography (hexane/EA 3:1).
4. Case Studies
Case 1: VEGFR Inhibitor Development
A research team synthesized eight carbonylpteridine derivatives using 4,6-Dichloro-5-nitropyrimidine as the starting material. Compound TM3 showed 78% inhibition against HepG2 cells at 10 μM.
Case 2: Ticagrelor Intermediate Production
Pharmaceutical manufacturer achieved 92% yield in large-scale synthesis of 4,6-Dichloro-5-nitro-2-propylthiopyrimidine (CAS 145783-14-8) under optimized Buchwald-Hartwig conditions.
5. Client Success Stories
Client A: Specialty Chemical Producer
Integrated 4,6-Dichloro-5-nitropyrimidine into their API production line, reducing synthesis steps by 40% for a kinase inhibitor project.
Client B: University Research Lab
Developed novel fluorescent probes using modified pyrimidine derivatives, published in ACS Applied Materials & Interfaces (2024).
6. Contact for Custom Solutions
Request tailored specifications or bulk pricing:
| info@vivalr.com | |
| Phone | (86) 15866781826 |
