5-Bromo-4,6-dichloropyrimidine

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Comprehensive Guide to 5-Bromo-4,6-dichloropyrimidine (CAS 68797-61-5)

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter 5-Bromo-4,6-dichloropyrimidine Analogous Compounds
CAS Number 68797-61-5 36082-50-5 (structural isomer)
Molecular Formula C4HBrCl2N2 C4HCl2N2Br
Molecular Weight 227.87 g/mol 227.87 g/mol
Purity Grade ≥98% (HPLC) 95-97% (standard)
Thermal Stability Stable below 230°C Decomposes at 200°C

2. Applications & Industrial Uses

This heterocyclic compound serves as a crucial building block in:

  • Pharmaceutical intermediates for kinase inhibitors
  • Agrochemical synthesis (herbicide precursors)
  • Organic electronic material development
  • Cross-coupling reactions in catalytic processes

3. Operational Guidelines

Handling Protocols:

  • Store in inert atmosphere at 2-8°C
  • Use corrosion-resistant equipment for processing
  • Maintain pH between 6.5-7.5 in aqueous solutions

Reactivity Profile:

  • Reacts vigorously with strong oxidizing agents
  • Compatible with Suzuki-Miyaura coupling conditions
  • Undergoes nucleophilic substitution at C-4 position

4. Industry Case Studies

Case 1: Anticancer Drug Development
A Shanghai-based biotech company utilized this compound as a core structure in tyrosine kinase inhibitor research, achieving 73% yield in lead compound optimization.

Case 2: OLED Material Synthesis
Jiangsu materials laboratory reported enhanced electron mobility (12.3 cm²/V·s) in semiconductor layers using brominated pyrimidine derivatives.

5. Client Success Stories

Client A: Contract Research Organization
Achieved 40% reduction in synthesis steps for antipsychotic API using our compound as a key intermediate (Batch size: 150kg, Purity: 99.2%).

Client B: Academic Research Institute
Published Nature Chemistry paper on novel C-H activation methods using this reagent, citing 89% reaction efficiency.

6. Procurement Consultation

For technical specifications, bulk pricing, or custom synthesis requirements:

  • Email: info@vivalr.com
  • Phone: (86) 15866781826

Our chemical engineering team provides:

  • Regulatory compliance documentation
  • Custom purity optimization (98-99.9%)
  • GMP-grade manufacturing options
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