4-(4-Aminophenoxy)-N-methylpicolinamide

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4-(4-Aminophenoxy)-N-methylpicolinamide: Technical Guide & Applications

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter 4-(4-Aminophenoxy)-N-methylpicolinamide Analogous Compounds
CAS Number 1353866-69-5 Varies by derivative
Molecular Formula C13H13N3O2 Typically C12-15H/N/O variants
Purity Grade >98% (HPLC) 90-99% commercial grades
Thermal Stability Stable up to 230°C 200-250°C range

2. Key Applications & Functional Insights

Pharmaceutical Intermediate: Critical building block for kinase inhibitors in oncology research.

Polymer Chemistry: Enables synthesis of heat-resistant polyamides in electronic encapsulation materials.

Analytical Reference Standard: USP-grade material for HPLC method development in QA/QC protocols.

3. Operational Best Practices

Storage: Maintain at 2-8°C under inert atmosphere (N2 or Argon)

Handling: Use glove boxes for oxygen-sensitive reactions

Solubility Optimization: 20-30 mg/mL in DMF/DMSO mixtures at 40°C

4. Industry Use Cases

Case 1: Anticancer Drug Development – EGFR inhibitor synthesis (Phase II clinical trials)

Case 2: Flexible Printed Circuit Production – Polyimide precursor synthesis

Case 3: Agricultural Chemistry – Fungicidal metabolite research

5. Client Success Stories

Client A: Top 10 Pharma Company
– Application: BTK inhibitor scale-up (2.5kg batch success)
– Result: 92% yield improvement vs. previous intermediates

Client B: Advanced Materials Manufacturer
– Application: High-Tg polymer membranes
– Outcome: 40% enhancement in thermal degradation resistance

6. Procurement Guidance

Supplier Selection Criteria:
– Batch-to-batch consistency documentation
– Regulatory support (REACH, TSCA compliance)
– Technical support responsiveness

Contact for Technical Consultation:
Email: info@vivalr.com
Tel: (86) 15866781826
Available: Mon-Fri 9:00-17:00 (GMT+8)

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