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4-Cyano-7-Azaindole: Comprehensive User Guide for Pharmaceutical and Research Applications

Table of Contents

1. Product Overview & Specifications

4-Cyano-7-Azaindole (CAS: Pending verification) is a heterocyclic compound with the molecular formula C8H5N3, featuring a cyano group at the 4-position of the azaindole scaffold. This structural configuration enables unique electronic properties for pharmaceutical intermediates and organic synthesis.

Comparative Analysis of Azaindole Derivatives
Parameter 4-Cyano-7-Azaindole 4-Chloro-6-Cyano-7-Azaindole 4-Methoxy-7-Azaindole
Molecular Weight 143.14 g/mol 177.59 g/mol 148.17 g/mol
CAS Number Under validation 935466-70-9 122379-63-9
Key Functional Group Cyano Chloro + Cyano Methoxy

*Specifications subject to batch-specific analysis. Contact technical support for certified COA.

2. Key Applications

2.1 Pharmaceutical Intermediates

Widely employed in kinase inhibitor development due to its ability to modulate enzyme binding affinity through π-π stacking interactions.

2.2 Material Science

Used in organic semiconductor research for electron-deficient building blocks in OLED architectures.

2.3 Agrochemical Development

Serves as a precursor for novel pesticides targeting insect GABA receptors.

3. Usage Scenarios

3.1 Medicinal Chemistry Protocol

Typical Suzuki coupling reaction conditions:

  • Catalyst: Pd(PPh3)4 (5 mol%)
  • Solvent: DME/H2O (3:1)
  • Temperature: 90°C under N2
  • Yield: 68-72% (HPLC purity >95%)

3.2 Handling Recommendations

  • Storage: -20°C under argon
  • Shelf Life: 24 months when unopened
  • Safety: Use NIOSH-approved respirator when handling powder

4. Customer Case Studies

4.1 Shanghai Yuanye Bio-Technology

Application: Synthesized BTK inhibitors for autoimmune disease research
Result: Achieved IC50 = 12 nM in cellular assays
Scale: 50g pilot batch production

4.2 Wuhan Ruhening Biotech

Application: Developed fluorescent probes for protein kinase detection
Result: λem = 498 nm with quantum yield Φ = 0.42
Scale: 10kg commercial production

5. Technical Inquiry

For bulk pricing, custom synthesis, or analytical data:
info@vivalr.com
(86) 15866781826

Request current lead times:
GMP-grade batches typically ship within 4-6 weeks

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

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We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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