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2,6-Dibromopyridin-3-amine: Technical Guide for Research and Industrial Applications

Table of Contents

1. Product Overview & Specifications

CAS No.: 39856-57-0

Molecular Formula: C5H4Br2N2

Molecular Weight: 251.91 g/mol

Purity: ≥98% (HPLC)

Storage: 2–8°C, protected from light

Comparative Analysis

Parameter 2,6-Dibromopyridin-3-amine 3-Amino-2-bromopyridine
CAS No. 39856-57-0 39856-58-1
Molecular Formula C5H4Br2N2 C5H5BrN2
Molecular Weight 251.91 173.01
Reactivity Dual bromine sites for cross-coupling Single bromine substitution

2. Key Applications in Pharmaceutical Chemistry

  • Intermediate for Kinase Inhibitors: Serves as a core building block in oncology drug candidates targeting tyrosine kinase pathways.
  • Antiviral Drug Synthesis: Used in the preparation of nucleotide analogs for hepatitis C and HIV therapeutics.
  • Material Science: Facilitates the synthesis of conductive polymers for organic electronics.
  • Agrochemical Development: Key precursor for herbicides and fungicides with enhanced bioavailability.

3. Synthesis and Reaction Case Studies

Case 1: Suzuki-Miyaura Cross-Coupling

In a 2024 study, researchers utilized 2,6-Dibromopyridin-3-amine to synthesize bipyridine ligands via Pd-catalyzed coupling, achieving 92% yield under mild conditions (60°C, 12h).

Case 2: Buchwald-Hartwig Amination

A 2023 pharmaceutical project demonstrated efficient C-N bond formation using this compound with aryl chlorides, producing antitumor agents with IC50 values < 50 nM.

4. Industry Client Success Stories

Client A: Top 10 Global Pharma Company

Integrated 2,6-Dibromopyridin-3-amine into their pipeline for a JAK2 inhibitor program, reducing synthesis steps by 40% compared to traditional routes.

Client B: Specialty Chemical Manufacturer

Scaled production of OLED materials using this compound as an electron-transport layer precursor, achieving 99.5% purity at metric ton scale.

5. Contact for Technical Support

For bulk pricing, SDS, or custom synthesis requirements:

Email: info@vivalr.com
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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

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Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
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More than 150 sets of equipment to ensure quality.

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Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

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Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

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5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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