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Comprehensive Guide to 3-Amino-Isonicotinic Acid Methyl Ester

Table of Contents

Product Overview & Specifications

3-Amino-Isonicotinic Acid Methyl Ester (CAS 131747-25-6) is a specialized heterocyclic compound widely used in pharmaceutical synthesis and agrochemical research.

Parameter Specification Comparison: Similar Esters
CAS Number 131747-25-6 3-Amino-Benzoic Acid Methyl Ester (CAS 52127-84-3)
Molecular Formula C7H8N2O2 C8H9NO2
Purity ≥98% (HPLC) Typically 95-97% in commercial grades
Solubility Soluble in DMSO, Methanol Limited solubility in polar solvents

Key Applications

Pharmaceutical Intermediates

Critical component in synthesizing anti-tuberculosis agents and kinase inhibitors. Enables precise molecular modifications in lead compound optimization.

Agrochemical Development

Used in creating novel fungicides with improved leaf adhesion and rainfastness properties. Particularly effective against Phytophthora infestans.

Coordination Chemistry

Acts as polydentate ligand in transition metal complexes for catalytic applications and materials science research.

Usage Guidelines

Recommended Protocols

  1. Handling: Use under inert atmosphere (N2 or Ar) for moisture-sensitive reactions
  2. Storage: Maintain at 2-8°C in sealed amber glass containers
  3. Reaction Conditions: Optimal performance at 60-80°C in DMF or THF solvents

Safety Information

Hazard Code Precaution First Aid
Xi Wear nitrile gloves and safety goggles Flush eyes with water for 15 minutes if contacted

Industry Case Studies

Case Study 1: Antiviral Drug Development

Client: European Pharma Research Group
Challenge: Improve bioavailability of NNRTI candidates
Solution: Used as key building block in scaffold modification
Result: Achieved 40% improvement in water solubility

Case Study 2: Next-Gen Fungicides

Client: Global Agrochemical Manufacturer
Challenge: Resistance management in Oomycete pathogens
Solution: Incorporated into novel SDHI fungicide design
Result: 98% efficacy at 50% reduced application rate

Contact for Custom Solutions

Optimize your synthesis with our technical expertise:

Why Choose Our Product?
- Batch-to-batch consistency (RSD <0.5%)
- Custom purity grades (98-99.9%)
- Technical support from PhD chemists

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

Does it support auditing?

Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

Whether to provide samples?

Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

User’evaluation of us

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