2-CHLOROPYRIMIDINE-5-BORONIC ACID

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2-CHLOROPYRIMIDINE-5-BORONIC ACID: Ultimate Guide for Researchers & Industrial Buyers

Table of Contents

1. Technical Specifications & Competitive Benchmarking

Parameter 2-Chloropyrimidine-5-boronic Acid 2-Fluoropyrimidine-5-boronic Acid 5-Bromo-2-chloropyrimidine
CAS Number 1073354-57-4 944401-70-5 849368-42-3
Molecular Formula C4H3BClN2O2 C4H3BFN2O2 C4H2BrClN2
Purity Grade ≥98% (HPLC) ≥97% ≥95%
Suzuki Reaction Yield 82-89% 75-81% N/A

2. Advanced Functional Applications

Pharmaceutical Development

  • Key intermediate for tyrosine kinase inhibitors
  • Building block for antiviral compound synthesis
  • Cross-coupling reactions in API production

Material Science Innovations

  • Conductive polymer precursor
  • OLED electron transport layer component
  • Coordination polymer framework construction

3. Operational Protocols & Best Practices

Suzuki-Miyaura Coupling Protocol

  1. Maintain inert atmosphere (N2/Ar)
  2. Optimal molar ratio 1:1.2 (boronic acid:halide)
  3. Recommended catalyst: Pd(PPh3)4 (2 mol%)

Storage & Handling

  • Store at 2-8°C under nitrogen
  • Desiccate with molecular sieves (3Å)
  • Reconstitute in anhydrous THF/DMF

4. Documented Client Implementations

Case 1: Oncology Drug Development

  • Client: Swiss Pharma Research Group
  • Application: Third-generation BTK inhibitor synthesis
  • Result: 78% coupling efficiency achieved

Case 2: Flexible Electronics Manufacturing

  • Client: Seoul Display Technologies
  • Application: Blue OLED emitter layer fabrication
  • Result: 18% EQE improvement

5. Technical & Commercial Consultation

For bulk pricing, custom synthesis, or analytical data:

Request SDS, COA, or stability data:

  • Specify required quantities (1g-100kg scale)
  • Provide application context for optimal purity recommendation
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