4-NITRO-PYRIDIN-3-YLAMINE: Comprehensive Product Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 1072-23-1 |
| Molecular Formula | C5H5N3O2 |
| Molecular Weight | 139.11 g/mol |
| Appearance | Yellow crystalline powder |
| Purity | ≥98% (HPLC) |
| Storage Conditions | 2-8°C in airtight container |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
2. Parameter Comparison with Similar Compounds
| Compound | Nitration Position | Reactivity | Pharma Applications | Stability |
|---|---|---|---|---|
| 4-Nitro-pyridin-3-ylamine | 4-NO₂, 3-NH₂ | High | Antibiotic intermediates | Stable under inert gas |
| 2-Nitro-pyridin-4-amine | 2-NO₂, 4-NH₂ | Moderate | Agrochemicals | Light-sensitive |
| 5-Nitro-pyridin-2-amine | 5-NO₂, 2-NH₂ | Low | Dyes | Hygroscopic |
3. Key Applications & Industrial Uses
- Pharmaceutical Synthesis: Intermediate for ciprofloxacin analogues and kinase inhibitors
- Agrochemicals: Precursor for herbicides with nitro-group reactivity
- Coordination Chemistry: Ligand in transition metal complexes for catalysis
- Material Science: Building block for conductive polymers
4. Usage Scenarios & Best Practices
Scenario 1: Antibiotic Intermediate Synthesis
Used in Step 3 of gyrase inhibitor production under nitrogen atmosphere at 60°C, achieving 82% yield when reacted with ethyl chloroformate.
Scenario 2: Catalytic Cross-Coupling Reactions
Employed as directing group in Pd-catalyzed C-H activation reactions (0.5 mol% catalyst loading, DMF solvent, 12h reaction time).
5. Verified Client Case Studies
Case 1: EuroPharma Solutions
- Application: Synthesis of novel quinolone antibiotics
- Volume: 150kg/year under GMP standards
- Result: Reduced synthesis steps from 7 to 4, saving 35% production costs
Case 2: AgroChem Innovations Ltd.
- Application: Development of nitro-containing fungicides
- Technical Requirement: ≥99% isotopic purity for metabolic studies
- Outcome: Successful EPA registration with 98.7% biological efficacy
6. Request Customized Solutions
Contact our technical team for:
- Bulk pricing (1kg to ton-scale quantities)
- Custom synthesis with modified functional groups
- Regulatory support (REACH, FDA DMF filings)
Email: info@vivalr.com
Tel: (86) 15866781826


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