4-NITRO-PYRIDIN-3-YLAMINE

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4-NITRO-PYRIDIN-3-YLAMINE: Comprehensive Product Guide

1. Product Overview & Specifications

Parameter Specification
CAS Number 1072-23-1
Molecular Formula C5H5N3O2
Molecular Weight 139.11 g/mol
Appearance Yellow crystalline powder
Purity ≥98% (HPLC)
Storage Conditions 2-8°C in airtight container
Solubility Soluble in DMSO, methanol; slightly soluble in water

2. Parameter Comparison with Similar Compounds

Compound Nitration Position Reactivity Pharma Applications Stability
4-Nitro-pyridin-3-ylamine 4-NO₂, 3-NH₂ High Antibiotic intermediates Stable under inert gas
2-Nitro-pyridin-4-amine 2-NO₂, 4-NH₂ Moderate Agrochemicals Light-sensitive
5-Nitro-pyridin-2-amine 5-NO₂, 2-NH₂ Low Dyes Hygroscopic

3. Key Applications & Industrial Uses

  • Pharmaceutical Synthesis: Intermediate for ciprofloxacin analogues and kinase inhibitors
  • Agrochemicals: Precursor for herbicides with nitro-group reactivity
  • Coordination Chemistry: Ligand in transition metal complexes for catalysis
  • Material Science: Building block for conductive polymers

4. Usage Scenarios & Best Practices

Scenario 1: Antibiotic Intermediate Synthesis

Used in Step 3 of gyrase inhibitor production under nitrogen atmosphere at 60°C, achieving 82% yield when reacted with ethyl chloroformate.

Scenario 2: Catalytic Cross-Coupling Reactions

Employed as directing group in Pd-catalyzed C-H activation reactions (0.5 mol% catalyst loading, DMF solvent, 12h reaction time).

5. Verified Client Case Studies

Case 1: EuroPharma Solutions

  • Application: Synthesis of novel quinolone antibiotics
  • Volume: 150kg/year under GMP standards
  • Result: Reduced synthesis steps from 7 to 4, saving 35% production costs

Case 2: AgroChem Innovations Ltd.

  • Application: Development of nitro-containing fungicides
  • Technical Requirement: ≥99% isotopic purity for metabolic studies
  • Outcome: Successful EPA registration with 98.7% biological efficacy

6. Request Customized Solutions

Contact our technical team for:

  • Bulk pricing (1kg to ton-scale quantities)
  • Custom synthesis with modified functional groups
  • Regulatory support (REACH, FDA DMF filings)

Email: info@vivalr.com
Tel: (86) 15866781826

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