2-Bromo-3-fluoropyridine

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2-Bromo-3-fluoropyridine: Comprehensive Product Guide

1. Product Overview & Specifications

Parameter 2-Bromo-3-fluoropyridine 3-Bromo-2-fluoropyridine
CAS Number 40273-45-8 36178-05-9
Molecular Formula C5H3BrFN C5H3BrFN
Molecular Weight 175.986 g/mol 175.986 g/mol
Appearance Colorless to pale yellow liquid Similar
Boiling Point 173.2°C ±20.0 (760 mmHg) 179.6°C ±20.0 (760 mmHg)
Density 1.7 g/cm³ 1.7 g/cm³
LogP 1.98 N/A

2. Key Applications

2-Bromo-3-fluoropyridine is a versatile intermediate in organic synthesis, widely used in:

  • Pharmaceuticals: Synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and antiviral drug development.
  • Agrochemicals: Production of advanced pesticides and herbicides due to its halogen-substituted pyridine structure.
  • Material Science: Building block for functionalized polymers and liquid crystals.
  • Cross-Coupling Reactions: Suzuki-Miyaura and Buchwald-Hartwig reactions for creating complex heterocyclic systems.

3. Usage Guidelines

Handling & Storage

  • Store in sealed containers at 2-8°C under inert gas (Ar/N2)
  • Use corrosion-resistant equipment (glass or PTFE-lined)

Safety Precautions

  • Wear PPE: Nitrile gloves, safety goggles, and lab coat
  • Handle in well-ventilated areas (fume hood recommended)

4. Case Studies

Case 1: Anticancer Drug Intermediate

A leading biotech company utilized 2-bromo-3-fluoropyridine as a key precursor in developing a tyrosine kinase inhibitor, achieving 92% yield in the final coupling step.

Case 2: Herbicide Development

Agrochemical researchers synthesized a novel pyridine-based herbicide showing 40% higher field efficacy compared to traditional compounds.

5. Customer Success Stories

Shanghai Macklin Biochemical

Integrated 2-bromo-3-fluoropyridine into their high-throughput screening platform, reducing synthesis time for fluorinated APIs by 35%.

Hubei Xinkang Material Science

Developed a patented catalytic process using this compound, achieving 99.5% purity in large-scale production batches.

6. Request a Quote

Contact our technical team for customized solutions:

Submit your requirements for:

  • Bulk pricing (25kg+ quantities)
  • Custom synthesis services
  • Technical documentation (CoA, MSDS)

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