2-Bromo-3-fluoropyridine: Comprehensive Product Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | 2-Bromo-3-fluoropyridine | 3-Bromo-2-fluoropyridine |
|---|---|---|
| CAS Number | 40273-45-8 | 36178-05-9 |
| Molecular Formula | C5H3BrFN | C5H3BrFN |
| Molecular Weight | 175.986 g/mol | 175.986 g/mol |
| Appearance | Colorless to pale yellow liquid | Similar |
| Boiling Point | 173.2°C ±20.0 (760 mmHg) | 179.6°C ±20.0 (760 mmHg) |
| Density | 1.7 g/cm³ | 1.7 g/cm³ |
| LogP | 1.98 | N/A |
2. Key Applications
2-Bromo-3-fluoropyridine is a versatile intermediate in organic synthesis, widely used in:
- Pharmaceuticals: Synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and antiviral drug development.
- Agrochemicals: Production of advanced pesticides and herbicides due to its halogen-substituted pyridine structure.
- Material Science: Building block for functionalized polymers and liquid crystals.
- Cross-Coupling Reactions: Suzuki-Miyaura and Buchwald-Hartwig reactions for creating complex heterocyclic systems.
3. Usage Guidelines
Handling & Storage
- Store in sealed containers at 2-8°C under inert gas (Ar/N2)
- Use corrosion-resistant equipment (glass or PTFE-lined)
Safety Precautions
- Wear PPE: Nitrile gloves, safety goggles, and lab coat
- Handle in well-ventilated areas (fume hood recommended)
4. Case Studies
Case 1: Anticancer Drug Intermediate
A leading biotech company utilized 2-bromo-3-fluoropyridine as a key precursor in developing a tyrosine kinase inhibitor, achieving 92% yield in the final coupling step.
Case 2: Herbicide Development
Agrochemical researchers synthesized a novel pyridine-based herbicide showing 40% higher field efficacy compared to traditional compounds.
5. Customer Success Stories
Shanghai Macklin Biochemical
Integrated 2-bromo-3-fluoropyridine into their high-throughput screening platform, reducing synthesis time for fluorinated APIs by 35%.
Hubei Xinkang Material Science
Developed a patented catalytic process using this compound, achieving 99.5% purity in large-scale production batches.
6. Request a Quote
Contact our technical team for customized solutions:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Submit your requirements for:
- Bulk pricing (25kg+ quantities)
- Custom synthesis services
- Technical documentation (CoA, MSDS)


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