4-Hydroxy-8-(Trifluoromethyl)Quinoline-3-Carboxylic Ethyl Ester Product Guide
Table of Contents
- Product Specifications & Comparative Analysis
- Industrial Applications
- Operational Guidelines
- Case Studies
- Client Success Stories
- Procurement Consultation
Product Specifications & Comparative Analysis
| Parameter | 4-Hydroxy-8-(Trifluoromethyl)Quinoline-3-Carboxylic Ethyl Ester | Analogous Compounds |
|---|---|---|
| CAS Number | 23851-84-5 | 23779-95-5 (Acid form) |
| Molecular Formula | C13H10F3NO3 | C12H8F3NO3 |
| HS Code | 29334990.90 (China) | 2933497000 (US) |
| Thermal Stability | 187-192°C | 175-185°C (Typical esters) |
Industrial Applications
Pharmaceutical Intermediate
Essential precursor in fluoroquinolone antibiotic synthesis, particularly for advanced generation antimicrobial agents requiring trifluoromethyl group integration.
Chemical Research
Key building block for developing novel heterocyclic compounds in medicinal chemistry programs, enabling structural modifications at C-3 and C-8 positions.
Operational Guidelines
Storage Protocol
- Maintain sealed containers under inert atmosphere (N2 or Ar)
- Store at 2-8°C with ≤40% relative humidity
Reaction Optimization
| Process | Optimal Conditions |
|---|---|
| Esterification | Ethanol reflux (78°C) with H2SO4 catalyst |
| Purification | Column chromatography (silica gel, hexane/EtOAc 3:1) |
Case Studies
Antibiotic Intermediate Production
Shanghai Tongwei Biotech achieved 22% yield improvement through controlled esterification at reduced pressure (200 mbar), minimizing thermal decomposition.
Material Science Application
YuanYe Bio utilized this compound as electron-deficient moiety in OLED material development, achieving 18% luminance efficiency enhancement.
Client Success Stories
Pharmaceutical Manufacturer (Zhejiang)
- Annual consumption: 850 kg
- Application: Gatifloxacin intermediate synthesis
- Purity requirement: ≥99.5% (HPLC)
Research Institute (Beijing)
- Project: Novel kinase inhibitors development
- Key achievement: 3 patent filings utilizing this compound
Procurement Consultation
For technical specifications, batch pricing, or regulatory documentation:
Contact: Vivalr Chemical Solutions
Email: info@vivalr.com
Tel: (86) 15866781826
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