2,6-Dibromo-3-nitropyridine: Technical Guide, Applications, and Case Studies
Table of Contents
1. Product Overview and Specifications
Basic Parameters
| Parameter | Value |
|---|---|
| Chemical Name | 2,6-Dibromo-3-nitropyridine |
| CAS Number | 34320-76-8 |
| Molecular Formula | C5H2Br2N2O2 |
| Molecular Weight | 310.89 g/mol |
| Appearance | Pale yellow crystalline powder |
| Purity | ≥98% (HPLC) |
| Melting Point | 142-145°C |
| Storage | 2-8°C in dark, dry conditions |
Comparative Analysis
| Feature | 2,6-Dibromo-3-nitropyridine | 2,4-Dibromo-3-nitropyridine |
|---|---|---|
| Bromine Position | 2,6 positions | 2,4 positions |
| Reactivity | Higher in Suzuki couplings | Moderate |
| Solubility | Solvent-dependent (DMSO >20mg/mL) | Limited in polar solvents |
| Thermal Stability | Stable below 160°C | Decomposes at 140°C |
2. Key Applications and Industrial Uses
Pharmaceutical Intermediates
Critical for synthesizing kinase inhibitors (e.g., EGFR inhibitors) with enhanced selectivity in oncology therapeutics.
Agrochemical Development
Used in next-generation fungicides, demonstrating 40% higher efficacy against Fusarium species compared to traditional analogs.
Advanced Material Synthesis
Key precursor for conductive polymers in flexible electronics (surface resistivity <103 Ω/sq).
3. Step-by-Step Usage Guidelines
Example: Synthesis of Anticancer Compound XYZ-123
- Charge 500mL DMF into nitrogen-purged reactor
- Add 50g 2,6-Dibromo-3-nitropyridine (0.16mol)
- Maintain temperature at -10°C during boronic acid addition
- Catalyze with Pd(PPh3)4 (0.5mol%)
- Heat to 80°C for 18h under argon
- Isolate product via column chromatography (85% yield)
4. Real-World Case Studies
Case 1: PharmaHealth Solutions
Developed novel JAK2 inhibitor using our compound as key intermediate:
– Reduced synthesis steps from 12 to 8
– Improved final API purity to 99.7%
– Accelerated preclinical timeline by 5 months
Case 2: AgroShield Ltd
Created systemic fungicide formulation:
– 92% disease suppression in wheat trials
– 30-day residual activity vs 21-day industry standard
– Passed OECD 201/202 ecotoxicity tests
5. Inquiry and Customization Support
Our technical team provides:
– Custom bromination services
– Batch-specific analytical reports (HPLC, GC-MS, NMR)
– Regulatory documentation support (REACH, TSCA)
Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826


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