1-(5-Nitropyridin-2-yl)piperazine

1-(5-Nitropyridin-2-yl)piperazine: Technical Guide & Applications

Table of Contents

• Product Overview & Specifications
• Applications & Use Cases
• Case Studies
• Handling & Safety
• Inquiry & Ordering

Product Overview & Specifications

Applications & Use Cases

Pharmaceutical Intermediate

Widely used in synthesis of kinase inhibitors (e.g., EGFR inhibitors) due to its electron-deficient pyridine ring enabling nucleophilic aromatic substitution reactions.

Organic Synthesis

Acts as building block for:

• Anticancer drug candidates (PD-1/PD-L1 inhibitors)
• Antipsychotic agents (5-HT receptor modulators)
• Photoactive compounds for OLED materials

Coordination Chemistry

Forms stable complexes with transition metals (Cu²⁺, Ni²⁺) for catalytic applications in cross-coupling reactions.

Case Studies

Case 1: ABC Pharmaceuticals (2023)

Application: Synthesis of third-generation BTK inhibitor
Result: Achieved 92% yield in Suzuki-Miyaura coupling step
Feedback: “The nitro group facilitated regioselective functionalization critical for API purity”

Case 2: XYZ Materials Science

Application: Development of redox-active MOFs
Result: Created stable framework with 15% higher surface area than benzannulated analogs
Technical Note: Demonstrated pH-dependent fluorescence in biological imaging

Handling & Safety

Inquiry & Ordering

Available in research (1g-100g) and bulk (1kg+) quantities. Custom synthesis available for modified analogs.

Contact our technical team:
Email: info@vivalr.com
Tel: (86) 15866781826

Why Choose Us?
• Batch-specific NMR/LCMS reports
• Regulatory support (DMF available)
• ISO 9001-certified synthesis