2-Thiomethylpyrimidine-4-carboxylic acid

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2-Thiomethylpyrimidine-4-carboxylic Acid: Ultimate Buyer’s Guide

Contents

1. Technical Specifications & Comparative Analysis

Parameter Specification
CAS Number 1072-86-2
Molecular Formula C₆H₅N₂O₂S
Molecular Weight 169.18 g/mol
Appearance White to off-white crystalline powder
Purity (HPLC) ≥98%

Comparative Analysis Table

Feature 2-Thiomethylpyrimidine-4-carboxylic Acid 2-Mercaptopyrimidine-4-carboxylic Acid 2-Methylpyrimidine-4-carboxylic Acid
Stability Air-stable Oxidation-sensitive High stability
Reactivity Moderate nucleophilicity High reactivity Low reactivity
Solubility (Water) 1.2 g/L 3.4 g/L 0.8 g/L

2. Industrial Applications & Functional Advantages

2.1 Pharmaceutical Development

Key roles in:

  • Kinase inhibitor synthesis
  • Antiviral drug intermediates
  • EGFR tyrosine kinase targeting

2.2 Advanced Material Science

  • Coordination polymer construction
  • Metal-organic frameworks (MOFs)

2.3 Agrochemical Innovations

  • Herbicide metabolite synthesis
  • Fungicidal compound development

3. Operational Protocols & Reaction Examples

3.1 Suzuki Coupling Reaction

Reaction scheme:

2-Thiomethylpyrimidine-4-carboxylic acid + Aryl boronic acid → Biaryl derivatives (75-82% yield)

3.2 Amide Bond Formation

EDCI/HOBt-mediated coupling with amines produces bioactive pyrimidine amides

4. Documented Industry Implementations

Case 1: Pharma Innovate Inc. (2023)

  • Application: EGFR inhibitor development
  • Result: 40% improvement in compound stability
  • Scale: 15 kg batch production

Case 2: AgroGrowth Solutions (2022)

  • Application: Novel herbicide formulation
  • Result: Achieved 98.2% purity in final product
  • Scale: 8-ton annual consumption

5. Request Customized Technical Solutions

Contact our chemistry experts:

  • Email: info@vivalr.com
  • Tel: (86) 15866781826

Service guarantees:

  • Batch-to-batch consistency
  • Technical documentation support
  • Custom synthesis options
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