2-Thiomethylpyrimidine-4-carboxylic Acid: Ultimate Buyer’s Guide
Contents
- Basic Information & Specifications
- Key Applications
- Operational Use Cases
- Industry Success Stories
- Request Customized Solutions
1. Technical Specifications & Comparative Analysis
| Parameter | Specification |
|---|---|
| CAS Number | 1072-86-2 |
| Molecular Formula | C₆H₅N₂O₂S |
| Molecular Weight | 169.18 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98% |
Comparative Analysis Table
| Feature | 2-Thiomethylpyrimidine-4-carboxylic Acid | 2-Mercaptopyrimidine-4-carboxylic Acid | 2-Methylpyrimidine-4-carboxylic Acid |
|---|---|---|---|
| Stability | Air-stable | Oxidation-sensitive | High stability |
| Reactivity | Moderate nucleophilicity | High reactivity | Low reactivity |
| Solubility (Water) | 1.2 g/L | 3.4 g/L | 0.8 g/L |
2. Industrial Applications & Functional Advantages
2.1 Pharmaceutical Development
Key roles in:
- Kinase inhibitor synthesis
- Antiviral drug intermediates
- EGFR tyrosine kinase targeting
2.2 Advanced Material Science
- Coordination polymer construction
- Metal-organic frameworks (MOFs)
2.3 Agrochemical Innovations
- Herbicide metabolite synthesis
- Fungicidal compound development
3. Operational Protocols & Reaction Examples
3.1 Suzuki Coupling Reaction
Reaction scheme:
2-Thiomethylpyrimidine-4-carboxylic acid + Aryl boronic acid → Biaryl derivatives (75-82% yield)
3.2 Amide Bond Formation
EDCI/HOBt-mediated coupling with amines produces bioactive pyrimidine amides
4. Documented Industry Implementations
Case 1: Pharma Innovate Inc. (2023)
- Application: EGFR inhibitor development
- Result: 40% improvement in compound stability
- Scale: 15 kg batch production
Case 2: AgroGrowth Solutions (2022)
- Application: Novel herbicide formulation
- Result: Achieved 98.2% purity in final product
- Scale: 8-ton annual consumption
5. Request Customized Technical Solutions
Contact our chemistry experts:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Service guarantees:
- Batch-to-batch consistency
- Technical documentation support
- Custom synthesis options
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