4-Amino-3-bromopyridine: Comprehensive User Guide
Table of Contents
1. Product Overview and Specifications
4-Amino-3-bromopyridine (CAS 13534-02-6) is a brominated pyridine derivative widely used in pharmaceutical and agrochemical synthesis. Key specifications include:
| Parameter | Value |
|---|---|
| Molecular Formula | C5H5BrN2 |
| Molecular Weight | 173.01 g/mol |
| Purity | ≥98% |
| Appearance | White to off-white crystalline powder |
Comparative Advantage: Unlike 3-amino-4-bromopyridine, this isomer offers higher reactivity in Suzuki-Miyaura cross-coupling reactions due to optimized steric effects.
2. Detailed Applications
4-Amino-3-bromopyridine serves as a critical building block in:
- Pharmaceuticals: Intermediate for kinase inhibitors and antiviral agents.
- Agrochemicals: Precursor for herbicides and fungicides.
- Material Science: Ligand in catalytic systems for OLED manufacturing.
3. Usage Instructions
Typical Reaction Protocol:
- Dissolve 1.0 eq of 4-amino-3-bromopyridine in dry THF under nitrogen.
- Add 1.2 eq of boronic acid and 2 mol% Pd(PPh3)4.
- Heat at 80°C for 12 hours.
- Purify via column chromatography (hexane:EtOAc = 3:1).
4. Case Studies
Case 1: Synthesis of EGFR inhibitor Osimertinib analog achieved 78% yield using this compound as key intermediate.
Case 2: Preparation of copper(I) complexes for OLED emitters demonstrated 15% higher quantum efficiency vs. chloro analogs.
5. Client Success Stories
| Client | Application | Result |
|---|---|---|
| PharmaTech Solutions (Germany) | Anticancer drug intermediate | Reduced synthesis steps from 5 to 3 |
| AgroNova Ltd (USA) | Herbicide lead optimization | Improved bioactivity by 40% |
6. Contact for Inquiries
Request custom synthesis quantities or technical support:
Email: info@vivalr.com
Phone: (86) 15866781826
✉️ Batch Certificates: Available upon request for regulatory compliance.
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