4-AMINO-7-(TRIFLUOROMETHYL)QUINOLINE

Table of Contents

• Product Overview
• Technical Specifications & Comparison
• Key Applications
• Usage Scenarios
• Client Success Stories
• Contact for Custom Solutions

4-Amino-7-(Trifluoromethyl)Quinoline Overview

This fluorinated quinoline derivative (CAS 112022-64-9) serves as a premium building block in pharmaceutical and advanced material synthesis. The trifluoromethyl group enhances both metabolic stability and lipophilicity compared to non-fluorinated analogs.

Technical Specifications & Competitive Analysis

Core Application Areas

Pharmaceutical Intermediate

Critical component in:

• Kinase inhibitor development (EGFR/VEGFR)
• Antimalarial drug candidates
• PET tracer precursors

Material Science

• OLED electron transport layers
• Coordination polymer synthesis

Implementation Scenarios

Lab-scale Synthesis Protocol

Typical reaction conditions:

Industrial Production

Batch process optimization parameters:

• 500L reactor capacity
• GMP-compliant purification
• 15kg/batch output

Documented Client Implementations

Case 1: Oncology Research Institute

Challenge: Develop brain-penetrant EGFR inhibitors
Solution: Utilized compound’s CF3 group for blood-brain barrier penetration
Outcome: 3 lead compounds with IC50 < 10nM

Case 2: Electronic Materials Producer

Challenge: Create stable blue OLED emitters
Solution: Incorporated as electron-deficient moiety
Result: 18% EQE improvement vs. baseline

Request Customized Solutions

Available modifications:

• Isotope-labeled versions (13C/15N)
• Bulk quantities (100kg+)
• GMP-grade material

Contact our technical team:
Email: info@vivalr.com
Tel: (86) 15866781826