Dextran sulfate sodium CAS 9011-18-1

Table of Contents

1. Product Overview

Dextran Sulfate Sodium (CAS 9011-18-1) is a sulfated polysaccharide widely used in biomedical research. With variable molecular weights (5-500 kDa), it serves as critical component in colitis induction, anticoagulant studies, and virology research.

2. Specifications & Parameter Comparison

3. Key Applications

3.1 Induction of Experimental Colitis

2-5% DSS solution in drinking water induces ulcerative colitis in rodents within 7 days, widely adopted for IBD mechanism studies.

3.2 Anticoagulant Research

Competes with heparin for binding to antithrombin III, used in thrombosis studies at 0.1-1 mg/mL concentrations.

3.3 Virology Applications

Enhances HIV infectivity in T-cell cultures at 10 μg/mL while inhibiting reverse transcriptase activity at higher concentrations (>100 μg/mL).

4. Experimental Usage Cases

4.1 Standard DSS Colitis Protocol

Step 1: Prepare 3% DSS solution in autoclaved water
Step 2: Administer to C57BL/6 mice ad libitum for 5-7 days
Result: Develops weight loss (>15%), bloody diarrhea, and colon shortening within 7 days

4.2 Antiviral Research Application

Used at 50 μg/mL concentration to enhance lentivirus transduction efficiency in HEK293 cells by 300% compared to PEI methods.

5. Verified Client Success Stories

Case 1: Pharmaceutical Research Institute (Germany)

Challenge: Needed reproducible IBD model for drug screening
Solution: Used 40kDa DSS at 2.5% concentration
Outcome: Achieved 90% model consistency across 15 test batches

Case 2: Biotech Startup (USA)

Challenge: Required HIV-1 concentration from cell culture media
Solution: Implemented 500kDa DSS precipitation protocol
Outcome: Increased viral yield by 40% vs ultracentrifugation

6. Request Customized Solutions

Optimize your research with tailored DSS specifications:
• Bulk order discounts (50kg+ quantities)
• Custom molecular weight modifications (5-800kDa)
• GMP-grade manufacturing available
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