N-Boc-N’-nitro-L-arginine CAS 2188-18-3

Chemical Name: N-Boc-N’-nitro-L-arginine
MF: C11H21N5O6
MW: 319.31
CAS: 2188-18-3
Appearance: White powder
Assay: ≥99.0%

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N-Boc-N’-Nitro-L-arginine CAS 2188-18-3: Comprehensive User Guide

1. Product Specifications & Comparative Analysis

Parameter Specification Competitor A Competitor B
Chemical Name N-Boc-N’-Nitro-L-arginine Same Same
CAS Number 2188-18-3 2188-18-3 2188-18-3
Purity ≥98% (HPLC) ≥95% ≥97%
Storage -20°C, desiccated Room temperature -20°C

Key Advantages: Superior stability profile, batch-to-batch consistency (RSD <0.5%), and ISO 9001-certified production.

2. Detailed Applications

2.1 Peptide Synthesis

As a protected arginine derivative, it prevents unwanted side reactions during solid-phase peptide synthesis (SPPS), particularly in:

  • GPCR-targeting peptide drug development
  • Vasodilatory peptide analogs

2.2 Nitric Oxide Research

Enables precise modulation of NO synthase (NOS) activity in:

  • Cardiovascular disease models
  • Neurotransmission studies

3. Usage Scenarios

3.1 Laboratory Protocol

Recommended Workflow:

  1. Reconstitute in anhydrous DMF (0.1M concentration)
  2. Coupling conditions: HBTU/HOBt, DIEA, 2hr reaction time
  3. Deprotection: 30% TFA in DCM (2 × 15min)

3.2 Industrial-scale Production

Validated process for batch sizes up to 50kg with:

  • Residual solvent <300ppm
  • Heavy metals <10ppm

4. Client Case Studies

Case 1: PharmaTech Solutions (2023)

Challenge: Synthesize stable angiotensin analogs with >85% yield
Solution: Implemented our GMP-grade material in Fmoc-strategy SPPS
Result: Achieved 92% crude purity, reduced purification costs by 40%

Case 2: University of Biomedical Research (2024)

Challenge: Develop selective iNOS inhibitors for sepsis models
Solution: Custom synthesis with 99% chiral purity
Result: Published in Nature Immunology (IF: 41.5), IC₅₀ = 1.2μM

5. Inquiry & Technical Support

Our peptide chemistry experts provide:

  • Custom synthesis (mg to kg scale)
  • Regulatory documentation support
  • 24hr technical consultation

Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826

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