N-Boc-N’-Nitro-L-arginine CAS 2188-18-3: Comprehensive User Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Chemical Name | N-Boc-N’-Nitro-L-arginine | Same | Same |
| CAS Number | 2188-18-3 | 2188-18-3 | 2188-18-3 |
| Purity | ≥98% (HPLC) | ≥95% | ≥97% |
| Storage | -20°C, desiccated | Room temperature | -20°C |
Key Advantages: Superior stability profile, batch-to-batch consistency (RSD <0.5%), and ISO 9001-certified production.
2. Detailed Applications
2.1 Peptide Synthesis
As a protected arginine derivative, it prevents unwanted side reactions during solid-phase peptide synthesis (SPPS), particularly in:
- GPCR-targeting peptide drug development
- Vasodilatory peptide analogs
2.2 Nitric Oxide Research
Enables precise modulation of NO synthase (NOS) activity in:
- Cardiovascular disease models
- Neurotransmission studies
3. Usage Scenarios
3.1 Laboratory Protocol
Recommended Workflow:
- Reconstitute in anhydrous DMF (0.1M concentration)
- Coupling conditions: HBTU/HOBt, DIEA, 2hr reaction time
- Deprotection: 30% TFA in DCM (2 × 15min)
3.2 Industrial-scale Production
Validated process for batch sizes up to 50kg with:
- Residual solvent <300ppm
- Heavy metals <10ppm
4. Client Case Studies
Case 1: PharmaTech Solutions (2023)
Challenge: Synthesize stable angiotensin analogs with >85% yield
Solution: Implemented our GMP-grade material in Fmoc-strategy SPPS
Result: Achieved 92% crude purity, reduced purification costs by 40%
Case 2: University of Biomedical Research (2024)
Challenge: Develop selective iNOS inhibitors for sepsis models
Solution: Custom synthesis with 99% chiral purity
Result: Published in Nature Immunology (IF: 41.5), IC₅₀ = 1.2μM
5. Inquiry & Technical Support
Our peptide chemistry experts provide:
- Custom synthesis (mg to kg scale)
- Regulatory documentation support
- 24hr technical consultation
Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826



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