4-(2-Bromoacetyl)benzonitrile Cas 20099-89-2

Chemical Name: 4-(2-Bromoacetyl)benzonitrile
Cas No.: 20099-89-2
Molecular Fomula: C9H6BrNO
Molecular Weight: 224.05
Appearance: Off-white to light yellow crystalline powder

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Table of Contents

1. Product Overview & Specifications

4-(2-Bromoacetyl)benzonitrile (CAS 20099-89-2)

Parameter Specification Comparison with Similar Compounds
Molecular Formula C9H5BrNO Higher reactivity vs. chloroacetyl analogs
Molecular Weight 223.05 g/mol Optimal for small-molecule synthesis
Appearance White to off-white crystalline powder Superior purity (≥98%) vs. standard grades
Melting Point 98-102°C Stable under ambient conditions
Storage 2-8°C in inert atmosphere Longer shelf-life than bromoacetophenone derivatives

2. Key Applications & Use Cases

Pharmaceutical Intermediate

Widely used in synthesis of kinase inhibitors and anticancer agents due to its dual functional groups enabling:

  • Nucleophilic substitution reactions
  • Suzuki-Miyaura cross-coupling
  • Cyclization reactions for heterocyclic systems

Agrochemical Development

Critical component in creating novel pesticides through:

  • Acetyl group bromination for targeted activity
  • Cyanobenzene moiety for enhanced stability

3. Industry Case Studies

Case Study 1: Oncology Drug Development

Client: Top 10 Global Pharma Company

Application: Synthesis of third-generation EGFR inhibitors

Result: 22% yield improvement vs. traditional bromoketone intermediates

Case Study 2: Agricultural Research

Client: EU-based Agrochemical Innovator

Application: Development of systemic fungicides

Result: Achieved 99.7% enantiomeric purity in final product

4. Handling & Safety Guidelines

Parameter Requirement
Personal Protection Nitrile gloves, chemical goggles
Ventilation Local exhaust required
Incompatibilities Strong bases, oxidizing agents
Spill Management Absorb with vermiculite, pH-neutralize

5. Request Customized Quotes

Our technical team provides:

  • Custom synthesis services (gram to kilogram scale)
  • GMP-grade production capabilities
  • Regulatory support for FDA/EMA submissions

Contact our specialists for formulation advice:

Email: info@vivalr.com
Phone: (86) 15866781826

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