5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide (CAS 52560-89-1) Comprehensive User Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | CAS 52560-89-1 | Similar Thiazole Derivatives |
|---|---|---|
| Molecular Formula | C8H5N2OS3 | C7H4N2S2 |
| Purity Grade | ≥99.5% (HPLC) | 97-98.5% |
| Thermal Stability | Stable up to 240°C | Degrades at 200°C |
Key Advantages: Enhanced electron-withdrawing properties compared to standard thiazole compounds, making it ideal for pharmaceutical intermediates and organic electronics.
2. Industrial Applications & Functional Mechanisms
2.1 Pharmaceutical Intermediates
Used in synthesis of kinase inhibitors targeting EGFR and VEGFR pathways, with 32% higher yield compared to traditional intermediates.
2.2 Organic Semiconductors
Enhances charge mobility (μ = 0.45 cm²/V·s) in thin-film transistors due to planar molecular structure.
3. Implementation Case Studies
3.1 Drug Development Optimization
Challenge: A biotech firm required improved solubility (≥5 mg/mL in PBS) for lead compound SD-325.
Solution: Incorporated CAS 52560-89-1 as core scaffold, achieving 6.2 mg/mL solubility with maintained bioactivity.
4. Verified Client Implementations
4.1 Shanghai PharmaTech Co., Ltd.
Application: HER2 inhibitor development
Result: Reduced IC50 from 18nM to 9.7nM in BT-474 cell lines
4.2 Munich Materials Science Institute
Application: Flexible OLED substrates
Result: Achieved 15% improvement in device luminance efficiency
5. Request Technical Consultation
Contact our chemistry experts for batch synthesis (1kg-100kg scale):
✉️ info@vivalr.com
+86 15866781826
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