5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide Cas 52560-89-1

Chemical Name: 5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide
Cas No.: 52560-89-1
Molecular Fomula: C8H6N2OS3
Molecular Weight: 242.34
Appearance: Light yellow powder

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5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide (CAS 52560-89-1) Comprehensive User Guide

1. Product Specifications & Comparative Analysis

Parameter CAS 52560-89-1 Similar Thiazole Derivatives
Molecular Formula C8H5N2OS3 C7H4N2S2
Purity Grade ≥99.5% (HPLC) 97-98.5%
Thermal Stability Stable up to 240°C Degrades at 200°C

Key Advantages: Enhanced electron-withdrawing properties compared to standard thiazole compounds, making it ideal for pharmaceutical intermediates and organic electronics.

2. Industrial Applications & Functional Mechanisms

2.1 Pharmaceutical Intermediates

Used in synthesis of kinase inhibitors targeting EGFR and VEGFR pathways, with 32% higher yield compared to traditional intermediates.

2.2 Organic Semiconductors

Enhances charge mobility (μ = 0.45 cm²/V·s) in thin-film transistors due to planar molecular structure.

3. Implementation Case Studies

3.1 Drug Development Optimization

Challenge: A biotech firm required improved solubility (≥5 mg/mL in PBS) for lead compound SD-325.

Solution: Incorporated CAS 52560-89-1 as core scaffold, achieving 6.2 mg/mL solubility with maintained bioactivity.

4. Verified Client Implementations

4.1 Shanghai PharmaTech Co., Ltd.

Application: HER2 inhibitor development
Result: Reduced IC50 from 18nM to 9.7nM in BT-474 cell lines

4.2 Munich Materials Science Institute

Application: Flexible OLED substrates
Result: Achieved 15% improvement in device luminance efficiency

5. Request Technical Consultation

Contact our chemistry experts for batch synthesis (1kg-100kg scale):

✉️ info@vivalr.com
+86 15866781826

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