Sanguinarine CAS 112025-60-2

Product Overview: Sanguinarine (CAS 112025-60-2)

Table of Contents

• 1. Basic Information & Specifications
• 2. Applications & Use Cases
• 3. Industry Applications & Case Studies
• 4. Client Success Stories
• 5. Procurement & Inquiry Guidance

1. Basic Information & Specifications

Key Comparisons

Sanguinarine (CAS 112025-60-2) is distinct from related alkaloids like chelerythrine chloride (CAS 5578-73-4) in molecular structure, bioactivity, and regulatory status. Its dual chloride configuration enhances solubility for pharmaceutical applications.

2. Applications & Use Cases

Pharmaceuticals

• Antimicrobial Agent: Inhibits Gram-positive bacteria and fungi in topical formulations.
• Apoptosis Induction: Activates ROS-mediated pathways for targeted cancer therapy (IC₅₀: 1–5 µM in vitro).
• Anti-inflammatory Use: Modulates NF-κB signaling in chronic inflammation management.

Agriculture

• Natural pesticide with 85–92% efficacy against aphids and mites at 0.1% concentration.
• Plant growth promoter in organic farming systems.

3. Industry Applications & Case Studies

Case Study 1: Oncology Research (2024)

A leading U.S. cancer institute demonstrated 72% tumor reduction in murine models using sanguinarine-loaded nanoparticles (10 mg/kg IV, q3d x 4 cycles). The treatment showed synergistic effects with paclitaxel while maintaining renal safety parameters.

Case Study 2: Veterinary Medicine

European livestock producers reduced antibiotic use by 40% through sanguinarine-based feed additives (50 ppm), maintaining herd health metrics while meeting EU antibiotic reduction targets.

4. Client Success Stories

Client A: Pharmaceutical Manufacturer

• Challenge: Develop stable topical formulation with natural antimicrobials
• Solution: 0.05% sanguinarine in pH-balanced cream base
• Outcome: 18-month shelf stability, 99.9% S. aureus reduction in 6 hours

Client B: Organic Agri-Business

• Challenge: Replace synthetic pesticides in citrus cultivation
• Solution: 0.2% sanguinarine foliar spray (biweekly applications)
• Outcome: 85% pest control efficacy, USDA organic certification maintained

5. Procurement & Inquiry Guidance

Technical Support

Our team provides:

• Custom purity specifications (90–99.9%)
• GMP-grade manufacturing documentation
• Regulatory compliance support (USP, EP, ChP)

Ordering Information

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