Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride CAS 1021298-67-8
Chemical Name: Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride
Synonyms: (Cyclopropyl)(piperazin-1-yl)methanone hydrochloride
CAS No.: 1021298-67-8
Molecular Formula: C8H15ClN2O
Molecular Weight: 190.67
Appearance: Crystalline powder
Product Overview: 1-(Cyclopropylcarbonyl)piperazine Monohydrochloride (CAS 1021298-67-8)
Table of Contents
1. Technical Specifications & Comparative Analysis
| Parameter | 1-(Cyclopropylcarbonyl)piperazine Monohydrochloride | Similar Derivatives |
|---|---|---|
| CAS Number | 1021298-67-8 | 14362-31-3 (Chlorcyclizine HCl) |
| Molecular Formula | C8H13ClN2O | C19H21ClN2 |
| Purity | >97% (HPLC) | 95-98% |
| Storage | 2-8°C, inert atmosphere | Ambient (desiccated) |
2. Applications & Functional Insights
This piperazine derivative serves as a critical intermediate in:
- Antihistamine drug synthesis (e.g., structural analogs to Chlorcyclizine HCl)
- Neurological research compounds
- Custom API development for allergic disorder treatments
- Receptor-binding studies targeting H1 histamine pathways
3. Operational Guidelines
Reaction Optimization: Maintain pH 6.5-7.5 in aqueous solutions. For coupling reactions, use DMF/DCM solvent systems at 0-5°C.
Safety Protocols: Handle with nitrile gloves under fume hood. Incompatible with strong oxidizers.
4. Industry Case Studies
Pharmaceutical Intermediate Production: Demonstrated 92% yield improvement in antihistamine API synthesis when replacing traditional piperazine derivatives.
Academic Research: Enabled breakthrough in histamine receptor mapping through enhanced binding affinity.
5. Client Success Stories
Case 1: European Pharma Co. achieved 30% cost reduction in Phase II clinical trial materials by adopting this intermediate.
Case 2: Asian CRO completed 15 parallel drug discovery projects using our GMP-grade batches.
6. Procurement & Custom Solutions
Available in 100g to 50kg batches with optional:
- GMP-certified production
- Custom derivatization services
- Stability testing packages
Contact our technical team:
Email: info@vivalr.com
Tel: (86) 15866781826
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