n-Tetradecyl-β-D-Maltoside (CAS 18449-82-6): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
n-Tetradecyl-β-D-Maltoside (CAS 18449-82-6) is a high-purity nonionic detergent widely used in membrane protein solubilization and stabilization. Key parameters:
| Parameter | Value |
|---|---|
| Molecular Weight | 692.87 g/mol |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥98% |
| Critical Micelle Concentration (CMC) | 0.0085% (w/v) |
| HLB Value | 13.3 |
2. Key Applications & Use Cases
2.1 Membrane Protein Research
Enables gentle extraction of integral membrane proteins while maintaining structural integrity for:
- X-ray crystallography studies
- Cryo-EM sample preparation
- Receptor-ligand binding assays
2.2 Biopharmaceutical Manufacturing
Critical for:
- Vaccine antigen stabilization
- Monoclonal antibody purification
- Liposome formulation
3. Performance Comparison
| Detergent | CMC (%w/v) | Protein Stability | Cost Efficiency |
|---|---|---|---|
| n-Tetradecyl-β-D-Maltoside | 0.0085 | Excellent | High |
| DDM (n-Dodecyl β-D-Maltoside) | 0.009 | Good | Medium |
| Octyl Glucoside | 0.6 | Fair | Low |
4. Industry Case Studies
Case 1: Structural Biology Research
Client: ABC Biotech (Cambridge, UK)
Challenge: Poor GPCR stability in crystallization trials
Solution: 0.03% n-Tetradecyl-β-D-Maltoside in purification buffer
Result: 40% improvement in crystal resolution
Case 2: Vaccine Development
Client: XYZ Pharma (Boston, USA)
Challenge: Viral envelope protein aggregation
Solution: 0.01% detergent in formulation buffer
Result: Stable antigen preservation for 12 months at 4°C
5. Request Quote or Samples
Technical Support: Our experts provide application-specific optimization guidance.
Contact:
Email: info@vivalr.com
Tel: (86) 15866781826
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