Chemical Name: 2-(1-Piperazinyl)pyrimidine
CAS No.: 20980-22-7
Molecular Fomula: C8H12N4
Molecular weight: 164.21
Appearance: Transparent yellow liquid
Parameter | 2-(1-Piperazinyl)pyrimidine | Conventional Alternatives |
---|---|---|
CAS Number | 20980-22-7 | Varies by compound |
Molecular Formula | C8H11N5 | Different nitrogen content |
Purity Grade | ≥98% (HPLC) | Typically 95-97% |
Thermal Stability | Stable up to 250°C | Decomposes at 200-220°C |
Pharmaceutical Intermediate: Critical component in kinase inhibitor synthesis for oncology therapeutics.
Agrochemical Development: Building block for novel pesticide formulations with enhanced bioactivity.
Research Applications: Utilized in PET radiotracer development for neurological studies.
Storage Protocol: Maintain under inert atmosphere at -20°C for long-term preservation.
Reaction Optimization: Recommended molar ratio 1:1.2 with carbonyl compounds in DMF solvent.
Safety Measures: Use NIOSH-approved respirators when handling powdered form.
Application: EGFR inhibitor development for non-small cell lung cancer
Result: Achieved 78% tumor growth inhibition in preclinical models
Application: Novel neonicotinoid derivative synthesis
Result: 40% improved pest resistance versus commercial benchmarks
Application: Dopamine receptor ligand optimization
Result: Reduced IC50 from 120nM to 18nM in lead compounds
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