Product Overview: Triphenylmethyl Chloride (CAS 76-83-5)
Table of Contents
1. Technical Specifications & Comparative Analysis
| Parameter | Triphenylmethyl Chloride | Triphenylmethane (CAS 519-73-3) | Trityl Bromide (CAS 596-43-0) |
|---|---|---|---|
| Chemical Formula | C19H15Cl | C19H16 | C19H15Br |
| Molecular Weight | 278.78 g/mol | 244.33 g/mol | 323.23 g/mol |
| Melting Point | 109-112°C | 90-94°C | 152-154°C |
| Boiling Point | 230-235°C at 20 mmHg | 360°C | 381.2°C |
| Refractive Index | 1.6281 | N/A | N/A |
2. Industrial Applications & Functional Mechanisms
Pharmaceutical Synthesis: Serves as a critical intermediate in cephalosporin antibiotics production and antiviral iodinated nucleoside development.
Organic Protection Reagent: Enables selective protection of hydroxyl, thiol, and amino groups during multi-step syntheses.
Polymer Chemistry: Functions as initiator in controlled polymerization processes for specialty resins.
3. Operational Best Practices
- Storage: Maintain inert atmosphere (N2/Ar) at 2-8°C
- Handling: Use dry glassware under moisture-free conditions
- Reaction Optimization: Employ 1.1-1.3 molar equivalents in protection reactions
4. Industry-Specific Implementations
Antibiotic Manufacturing
Enables cephem ring formation through trityl-mediated hydroxyl protection.
Bioconjugate Chemistry
Facilitates reversible amine protection in peptide-drug conjugate synthesis.
5. Client Success Stories
Case 1: European Pharma Innovator
Challenge: Required high-purity tritylating agent for GMP-compliant antibiotic production.
Solution: Customized purification protocol achieving ≥99.8% HPLC purity.
Outcome: 22% yield improvement in final API crystallization.
Case 2: Asian Research Consortium
Challenge: Needed stable hydroxyl protection for marine natural product synthesis.
Solution: Optimized tritylation conditions with 93% protection efficiency.
Outcome: Successful completion of 15-step terpenoid synthesis.
6. Procurement Consultation
Request technical specifications or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826
Available formats: 1kg vacuum-sealed flasks, 25kg drum quantities
Global shipping: DDP incoterms available
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