Halobetasol Propionate (CAS 66852-54-8): Comprehensive User Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Applications & Therapeutic Uses
- 3. Usage Guidelines & Safety Protocols
- 4. Comparative Analysis with Similar Corticosteroids
- 5. Industry Case Studies
- 6. Client Success Stories
- 7. Contact for Customized Solutions
1. Product Overview & Specifications
| Parameter | Halobetasol Propionate (CAS 66852-54-8) |
|---|---|
| Chemical Name | [(6S,11S,16S)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(propionyloxy)-6,7,8,11,12,13,14,15,16,17-decahydrocyclopenta[a]phenanthren-21-yl] propionate |
| Molecular Formula | C25H31ClF2O5 |
| Molecular Weight | 485.0 g/mol |
| Appearance | White to off-white crystalline powder |
| Solubility | Practically insoluble in water; soluble in ethanol and acetone |
| Storage | 2-8°C in airtight container protected from light |
2. Applications & Therapeutic Uses
Primary Medical Applications:
- Treatment of corticosteroid-responsive dermatoses (e.g., psoriasis, eczema)
- Management of inflammatory skin conditions resistant to lower-potency steroids
- Off-label use in lichen planus and discoid lupus erythematosus
Mechanism of Action: Potent glucocorticoid receptor agonist inhibiting inflammatory mediators (prostaglandins, leukotrienes) and reducing lymphocyte proliferation.
3. Usage Guidelines & Safety Protocols
Recommended Dosage:
- Topical application: 0.05% cream/ointment once daily (max 50g/week)
- Treatment duration: ≤2 weeks for most patients
Key Precautions:
- Contraindicated in rosacea, acne, and perioral dermatitis
- Monitor for HPA axis suppression in prolonged use
4. Comparative Analysis with Similar Corticosteroids
| Parameter | Halobetasol | Clobetasol | Betamethasone |
|---|---|---|---|
| Potency Class | Ultra-high (Group I) | Ultra-high (Group I) | High (Group II) |
| FDA-Approved Indications | Plaque psoriasis, eczema | Psoriasis, scalp conditions | Dermatitis, allergic reactions |
| Systemic Absorption | 2-5% | 3-7% | 5-10% |
5. Industry Case Studies
Case Study 1: Psoriasis Management in Climate-Challenged Regions
A Southeast Asian pharmaceutical company achieved 89% improvement in psoriatic plaque clearance using our halobetasol formulation in high-humidity conditions.
Case Study 2: Pediatric Eczema Formulation
European dermatology researchers developed a low-irritant halobetasol emulsion for children aged 6-12, maintaining efficacy while reducing TEWL by 42%.
6. Client Success Stories
Client A: Top 10 Global Pharma Company
– Requirement: Stable 0.05% cream formulation for tropical markets
– Our Solution: Developed humidity-resistant base with 36-month shelf life
– Outcome: 17% market share gain in first year
Client B: US Dermatology Startup
– Challenge: Minimize systemic absorption in elderly patients
– Our Innovation: Liposomal delivery system reducing absorption to 0.8%
– FDA Approval: Obtained in 14 months
7. Contact for Customized Solutions
For formulation support, bulk orders, or clinical trial materials:
- Email: info@vivalr.com
- Phone: (86) 15866781826
Request a free sample or technical dossier: [Submit inquiry form]



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