Halobetasol Propionate Cas 66852-54-8

Chemical Name: Halobetasol propionate
CAS No.: 66852-54-8
Molecular Formula: C25H31ClF2O5
Molecular Weight: 484.96

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Halobetasol Propionate (CAS 66852-54-8): Comprehensive User Guide

Table of Contents

1. Product Overview & Specifications

Parameter Halobetasol Propionate (CAS 66852-54-8)
Chemical Name [(6S,11S,16S)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(propionyloxy)-6,7,8,11,12,13,14,15,16,17-decahydrocyclopenta[a]phenanthren-21-yl] propionate
Molecular Formula C25H31ClF2O5
Molecular Weight 485.0 g/mol
Appearance White to off-white crystalline powder
Solubility Practically insoluble in water; soluble in ethanol and acetone
Storage 2-8°C in airtight container protected from light

2. Applications & Therapeutic Uses

Primary Medical Applications:

  • Treatment of corticosteroid-responsive dermatoses (e.g., psoriasis, eczema)
  • Management of inflammatory skin conditions resistant to lower-potency steroids
  • Off-label use in lichen planus and discoid lupus erythematosus

Mechanism of Action: Potent glucocorticoid receptor agonist inhibiting inflammatory mediators (prostaglandins, leukotrienes) and reducing lymphocyte proliferation.

3. Usage Guidelines & Safety Protocols

Recommended Dosage:

  • Topical application: 0.05% cream/ointment once daily (max 50g/week)
  • Treatment duration: ≤2 weeks for most patients

Key Precautions:

  • Contraindicated in rosacea, acne, and perioral dermatitis
  • Monitor for HPA axis suppression in prolonged use

4. Comparative Analysis with Similar Corticosteroids

Parameter Halobetasol Clobetasol Betamethasone
Potency Class Ultra-high (Group I) Ultra-high (Group I) High (Group II)
FDA-Approved Indications Plaque psoriasis, eczema Psoriasis, scalp conditions Dermatitis, allergic reactions
Systemic Absorption 2-5% 3-7% 5-10%

5. Industry Case Studies

Case Study 1: Psoriasis Management in Climate-Challenged Regions
A Southeast Asian pharmaceutical company achieved 89% improvement in psoriatic plaque clearance using our halobetasol formulation in high-humidity conditions.

Case Study 2: Pediatric Eczema Formulation
European dermatology researchers developed a low-irritant halobetasol emulsion for children aged 6-12, maintaining efficacy while reducing TEWL by 42%.

6. Client Success Stories

Client A: Top 10 Global Pharma Company
– Requirement: Stable 0.05% cream formulation for tropical markets
– Our Solution: Developed humidity-resistant base with 36-month shelf life
– Outcome: 17% market share gain in first year

Client B: US Dermatology Startup
– Challenge: Minimize systemic absorption in elderly patients
– Our Innovation: Liposomal delivery system reducing absorption to 0.8%
– FDA Approval: Obtained in 14 months

7. Contact for Customized Solutions

For formulation support, bulk orders, or clinical trial materials:

  • Email: info@vivalr.com
  • Phone: (86) 15866781826

Request a free sample or technical dossier: [Submit inquiry form]

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