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Specialized inLithium Bis(trimethylsilyl)amide Cas 4039-32-1and related product development and production

Chemical Name: Lithium bis(trimethylsilyl)amide
CAS No.: 4039-32-1
Molecular Formula: C6H18LiNSi2
Molecular Weight: 167.33

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

Lithium Bis(trimethylsilyl)amide (LiHMDS, CAS 4039-32-1): Comprehensive User Guide

Table of Contents

1. Product Overview & Parameter Comparison

Key Specifications

Parameter LiHMDS (CAS 4039-32-1) NaHMDS KHMDS
Molecular Formula C6H18LiNSi2 C6H18NNaSi2 C6H18KNSi2
Molecular Weight 199.34 g/mol 215.37 g/mol 231.48 g/mol
Basicity (pKa) ~26 (THF) ~24 ~22
Solubility Excellent in THF, hydrocarbons Moderate in polar solvents Limited in non-polar media

*Data based on 1M solutions in THF at 25°C.

2. Detailed Applications

Core Use Cases

  • Enolate Formation: Superior for regioselective deprotonation of carbonyl compounds
  • Polymerization: Initiator for anionic polymerization of styrenes and acrylates
  • Asymmetric Synthesis: Chiral auxiliary activation in pharmaceutical intermediates
  • Silylation Reactions: Efficient silylating agent for hydroxyl groups

3. Usage Scenarios & Case Studies

Pharmaceutical Synthesis

Challenge: Low yield (38%) in β-lactam antibiotic intermediate synthesis
Solution: LiHMDS-mediated ketone deprotonation at -78°C
Result: 82% yield with >99% regioselectivity

OLED Material Production

Challenge: Inconsistent molecular weights in electroluminescent polymer synthesis
Solution: 0.05 mol% LiHMDS initiator in THF at 60°C
Result: PDI reduced from 1.8 to 1.12 with Mn=45,000 Da

4. Real Customer Success Stories

Case 1: Top-10 Pharma Company (API Production)

Parameter Before LiHMDS After LiHMDS
Reaction Time 18 hours 4.5 hours
Yield 67% 91%
Impurity Profile 3.2% by HPLC 0.8% by HPLC

Case 2: Specialty Chemical Manufacturer

Enabled synthesis of novel silicone-polyamide hybrids with:
- 40% higher thermal stability (Tg from 120°C to 168°C)
- 25% reduction in production costs

5. Contact for Customized Solutions

Optimize your processes with our LiHMDS expertise:
Email: info@vivalr.com
Phone: (86) 15866781826

Request free technical consultation or sample evaluation today.

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

Does it support auditing?

Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

Whether to provide samples?

Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

User’evaluation of us

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" Sincere Chemical team visited our USA factory in the year of 2017. We think highly of cooperation with them. We thanked you for the past excellent orders and best product quality. We also talked about some new products for future orders. We will be still in strategic cooperation in the future and help each other."

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