Lithium Bis(trimethylsilyl)amide (LiHMDS, CAS 4039-32-1): Comprehensive User Guide
Table of Contents
1. Product Overview & Parameter Comparison
Key Specifications
| Parameter | LiHMDS (CAS 4039-32-1) | NaHMDS | KHMDS |
|---|---|---|---|
| Molecular Formula | C6H18LiNSi2 | C6H18NNaSi2 | C6H18KNSi2 |
| Molecular Weight | 199.34 g/mol | 215.37 g/mol | 231.48 g/mol |
| Basicity (pKa) | ~26 (THF) | ~24 | ~22 |
| Solubility | Excellent in THF, hydrocarbons | Moderate in polar solvents | Limited in non-polar media |
*Data based on 1M solutions in THF at 25°C.
2. Detailed Applications
Core Use Cases
- Enolate Formation: Superior for regioselective deprotonation of carbonyl compounds
- Polymerization: Initiator for anionic polymerization of styrenes and acrylates
- Asymmetric Synthesis: Chiral auxiliary activation in pharmaceutical intermediates
- Silylation Reactions: Efficient silylating agent for hydroxyl groups
3. Usage Scenarios & Case Studies
Pharmaceutical Synthesis
Challenge: Low yield (38%) in β-lactam antibiotic intermediate synthesis
Solution: LiHMDS-mediated ketone deprotonation at -78°C
Result: 82% yield with >99% regioselectivity
OLED Material Production
Challenge: Inconsistent molecular weights in electroluminescent polymer synthesis
Solution: 0.05 mol% LiHMDS initiator in THF at 60°C
Result: PDI reduced from 1.8 to 1.12 with Mn=45,000 Da
4. Real Customer Success Stories
Case 1: Top-10 Pharma Company (API Production)
| Parameter | Before LiHMDS | After LiHMDS |
|---|---|---|
| Reaction Time | 18 hours | 4.5 hours |
| Yield | 67% | 91% |
| Impurity Profile | 3.2% by HPLC | 0.8% by HPLC |
Case 2: Specialty Chemical Manufacturer
Enabled synthesis of novel silicone-polyamide hybrids with:
– 40% higher thermal stability (Tg from 120°C to 168°C)
– 25% reduction in production costs
5. Contact for Customized Solutions
Optimize your processes with our LiHMDS expertise:
Email: info@vivalr.com
Phone: (86) 15866781826
Request free technical consultation or sample evaluation today.
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