2-Methyltetrahydrofuran (Cas 96-47-9): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2-Methyltetrahydrofuran (2-MeTHF) (CAS 96-47-9) is a polar aprotic solvent with increasing adoption across pharmaceutical, chemical, and research sectors due to its superior environmental profile compared to traditional solvents.
| Parameter | Specification |
|---|---|
| CAS Number | 96-47-9 |
| Molecular Formula | C5H10O |
| Purity | ≥99.5% (GC) |
| Boiling Point | 80-82°C |
| Flash Point | -11°C (Closed Cup) |
| Density | 0.855 g/cm³ at 20°C |
2. Comparative Analysis with Alternative Solvents
| Property | 2-MeTHF | THF | Dioxane |
|---|---|---|---|
| Biodegradability | High | Low | Very Low |
| Water Miscibility | Partial (8.3g/100ml) | Complete | Complete |
| Dielectric Constant | 6.2 | 7.6 | 2.2 |
| Typical Applications | Grignard Reactions, Extractions | Polymerization | Lab Solvent |
3. Industrial Applications
3.1 Pharmaceutical Manufacturing
- Preferred solvent for oxygen-sensitive reactions
- Extraction medium for natural products
3.2 Specialty Chemicals
- Reaction medium for organometallic compounds
- Co-solvent in polyurethane formulations
4. Usage Scenarios & Best Practices
Case Study: API Synthesis
In the synthesis of Atorvastatin intermediates, 2-MeTHF demonstrated:
- 15% higher yield vs. THF
- Reduced purification steps
5. Client Success Stories
Client A: European Pharma Leader
- Challenge: THF residue in final API batches
- Solution: Transitioned to 2-MeTHF purification
- Outcome: 99.9% purity achieved, reduced waste
Client B: US Chemical Innovator
- Challenge: Inconsistent polymerization rates
- Solution: 2-MeTHF co-solvent system
- Outcome: 22% faster reaction kinetics
6. Request Customized Solutions
Contact our technical team for application support:
Email: info@vivalr.com
Phone: (86) 15866781826
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