RINK AMIDE AM RESIN CAS 183599-10-2

RINK AMIDE AM RESIN CAS 183599-10-2: Comprehensive User Guide

Table of Contents

1. Product Overview & Specifications
2. Key Applications
3. Operational Guidelines
4. Industry Case Studies
5. Contact for Technical Consultation

1. Product Specifications & Comparative Analysis

2. Core Applications

2.1 Solid-Phase Peptide Synthesis (SPPS)

Enables efficient C-terminal amide formation in Fmoc/t-Bu strategies, particularly effective for:

• Difficult sequence peptides (e.g., hydrophobic clusters)
• Cyclic peptide construction
• Post-synthetic modifications

2.2 Combinatorial Chemistry

Preferred matrix for:

• Parallel synthesis of compound libraries
• DNA-encoded chemical library production
• High-throughput screening preparations

3. Operational Protocol

3.1 Storage & Handling

Optimal storage conditions: 2-8°C in sealed container with desiccant

3.2 Synthesis Workflow

1. Pre-swelling: 30 min in DMF/DCM (3:1)
2. Fmoc deprotection: 20% piperidine/DMF (2×5 min)
3. Coupling: 3×1 hr with 3 eq amino acid/HATU/DIEA
4. Final cleavage: TFA/H2O/TIS (95:2.5:2.5) 2hr

4. Verified Application Cases

Case 1: Pharmaceutical Development

Client: Top 10 Global Pharma Company
Application: GLP-1 Analog Production
Result: 92% purity achieved in 15-mer peptide

Case 2: Research Institution

Client: MIT Chemical Biology Lab
Application: PROTAC Molecule Library
Output: 1,200 novel compounds synthesized

Case 3: Biotech Startup

Client: NextGen Bio Therapeutics
Application: Antibody-Drug Conjugates
Yield Improvement: 40% vs traditional methods

5. Technical Consultation

For batch-specific specifications or custom requirements:
Email: info@vivalr.com
Tel: (86) 15866781826

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