Colistin Sulfate (CAS 1264-72-8) Comprehensive User Guide

1. Product Overview & Specifications

Basic Parameters

Comparative Analysis

2. Key Applications & Mechanism

Primary Use: Broad-spectrum polypeptide antibiotic targeting Gram-negative bacteria (e.g., E. coli, Pseudomonas aeruginosa, Klebsiella pneumoniae).

Mechanism: Binds to lipopolysaccharides (LPS) and phospholipids in bacterial outer membranes, disrupting membrane integrity via detergent-like action. Effective against multidrug-resistant strains.

Clinical Relevance: Critical for treating hospital-acquired infections, particularly in ICU settings where resistance to other antibiotics is prevalent.

3. Usage Scenarios

• Pharmaceutical Manufacturing: Active ingredient in injectable antibiotics for systemic infections.
• Veterinary Medicine: Growth promoter and therapeutic agent in livestock feed.
• Research: Standard reference material for antimicrobial susceptibility testing (AST).

4. Verified Customer Cases

Case 1: ChemeGen China

Application: Supplied 98% purity Colistin Sulfate to a Shanghai biomedical research institute for developing rapid diagnostic kits for carbapenem-resistant pathogens. Reported 99% batch consistency over 12 months.

Case 2: Wuhan Wislman Bio

Application: Provided bulk quantities (1 kg batches) to a pharmaceutical manufacturer in Guangdong for producing ICU-targeted antibiotics. Achieved 30% reduction in production costs through optimized formulations.

Case 3: Hubei Changxinsheng Chemical

Application: Delivered 99% purity material to a veterinary feed additive company in Henan. Improved livestock survival rates by 22% in controlled trials against avian colibacillosis.

5. Request Quotation

For bulk pricing, COA documentation, or custom formulations:

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