Table of Contents
- Artesunate (CAS 88495-63-0) Overview
- Technical Specifications & Comparative Analysis
- Pharmaceutical Applications & Mechanisms
- Clinical Usage Guidelines
- Therapeutic Case Studies
- Enterprise Client Success Stories
- Expert Consultation & Quotation
Artesunate (CAS 88495-63-0) Overview
Artemisinin-derived antimalarial compound with molecular formula C19H28O8, widely recognized by WHO as first-line treatment for severe malaria. This water-soluble hemisuccinate derivative demonstrates rapid parasitic clearance rates and improved bioavailability compared to other artemisinin analogs.
Technical Specifications & Comparative Analysis
| Parameter | Artesunate | Artemether | Dihydroartemisinin |
|---|---|---|---|
| CAS Number | 88495-63-0 | 71963-77-4 | 81496-81-3 |
| Half-life (IV) | 0.6-1.2 hours | 3-11 hours | 1.5-3 hours |
| Water Solubility | ≥50 mg/mL | Insoluble | Poor |
Pharmaceutical Applications & Mechanisms
Primary applications include:
- Severe Plasmodium falciparum malaria treatment (IV/IM)
- Adjuvant therapy in cerebral malaria
- Multidrug-resistant malaria management
- Emerging research in anticancer applications (Phase II trials)
- COVID-19 related cytokine storm management (investigational)
Clinical Usage Guidelines
Standard dosage protocols:
| Patient Group | Initial Dose | Maintenance Dose |
|---|---|---|
| Adults (IV) | 2.4 mg/kg | 1.2 mg/kg at 12h/24h |
| Pediatric (IM) | 3.0 mg/kg | 1.5 mg/kg daily |
Therapeutic Case Studies
Case 1: 38-year-old male with cerebral malaria in Ghana showed 92% parasite reduction within 12 hours post-IV administration. Full parasite clearance achieved within 72 hours with adjunctive therapy.
Enterprise Client Success Stories
Dafra Pharma: Integrated Artesunate API in their malaria rapid response kits, achieving 99.7% batch consistency across 15 production cycles.
Guilin Pharmaceutical: Developed temperature-stable Artesunate tablets for tropical deployment, extending shelf-life from 18 to 36 months.
Expert Consultation & Quotation
Contact our pharmaceutical specialists:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Request batch-specific COA, DMF filings, or custom formulation development.
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