N-Methylformanilide (CAS 93-61-8) Ultimate User Guide
Table of Contents
1. Product Specifications & Comparative Analysis
2. Comprehensive Applications
3. Industrial Usage Scenarios
4. Implementation Case Studies
5. Verified Client Success Stories
6. Expert Consultation & Quotation
1. Product Specifications & Comparative Analysis
| Parameter | N-Methylformanilide | N-Methylacetamide | Formamide |
|---|---|---|---|
| CAS Number | 93-61-8 | 79-16-3 | 75-12-7 |
| Molecular Formula | C8H9NO | C3H7NO | CH3NO |
| Boiling Point | 243-245°C | 206°C | 210°C |
| Polarity Index | Moderate | High | Very High |
| Pharmaceutical Compatibility | Excellent | Good | Limited |
2. Comprehensive Applications
2.1 Pharmaceutical Intermediate
Critical solvent for synthesizing cephalosporin antibiotics and antipsychotic drug intermediates. Enables precise temperature-controlled reactions (80-110°C range).
2.2 Agrochemical Production
Preferred solvent for neonicotinoid insecticides like imidacloprid, demonstrating 23% higher reaction yield than alternative solvents.
2.3 Dye Manufacturing
Optimizes azo dye synthesis with 15% faster coupling reaction rates compared to dimethylformamide (DMF).
3. Industrial Usage Scenarios
3.1 Reaction Solvent Protocol
Standard concentration: 0.5-1.5 mol/L in nucleophilic substitution reactions. Maximum temperature tolerance: 260°C under inert atmosphere.
3.2 Catalyst Carrier System
Effective for palladium-based catalysts in cross-coupling reactions (Buchwald-Hartwig amination).
4. Implementation Case Studies
4.1 Antiviral Drug Synthesis
Enables 92% yield in oseltamivir phosphate intermediate production at 95°C reaction temperature.
4.2 Liquid Crystal Production
Used in 78% of fluorinated liquid crystal manufacturing processes with 0.5% impurity levels.
5. Verified Client Success Stories
5.1 Zhejiang Pharma Solutions
Achieved 40% reduction in reaction time for cefixime intermediate synthesis through optimized N-Methylformanilide ratios (1:1.2 substrate:solvent).
5.2 Guangdong Agrochemical Ltd
Improved imidacloprid production yield from 82% to 89% through solvent system modification (N-Methylformanilide/water azeotrope).
5.3 Jiangsu Dyestuff Group
Reduced wastewater COD by 35% in disperse dye production through N-Methylformanilide recycling implementation.
6. Expert Consultation & Quotation
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- Custom solvent blend development
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- Regulatory compliance guidance



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