Salsalate (CAS 552-94-3): Technical Specifications, Applications, and Clinical Insights
Table of Contents
1. Chemical Profile & Specifications
| Parameter | Value | Regulatory Compliance |
|---|---|---|
| CAS Number | 552-94-3 | USP/EP Standards |
| Molecular Formula | C14H10O5 | IUPAC Certified |
| Molecular Weight | 258.226 g/mol | ISO 9001:2015 |
| Melting Point | 139-151°C | Ph. Eur. 10.0 |
| Boiling Point | 482.9°C @ 760 mmHg | ASTM E537 |
| Solubility | Ethanol: >100 mg/mL Water: Insoluble |
OECD 105 |
2. Pharmacological Applications
2.1 Anti-Inflammatory Action
As a non-acetylated salicylate derivative, salsalate inhibits prostaglandin synthesis via cyclooxygenase (COX) pathway modulation, demonstrating 85-90% efficacy in rheumatoid arthritis management compared to standard NSAIDs.
2.2 Metabolic Modulation
Clinical trials demonstrate salsalate’s capacity to reduce fasting glucose levels by 0.5 mmol/L (p<0.01) and improve insulin sensitivity index by 20% in type 2 diabetes patients through NF-κB pathway inhibition.
3. Industrial Use Cases
3.1 Pharmaceutical Synthesis
Used as intermediate in production of:
- Low-dose NSAID formulations (500-750 mg BID)
- Co-crystals with improved bioavailability
- Gastro-resistant tablet coatings
3.2 Analytical Reference Standards
Certified purity grades:
| Grade | Purity | Application |
|---|---|---|
| USP | ≥99.5% | Pharmaceutical QC |
| HPLC | ≥98.0% | Research Use |
4. Clinical Research Case Studies
4.1 TINSAL-T2D Trial (2013)
286 patients with HbA1c 7-9.5% showed:
- 0.3% reduction in HbA1c vs placebo (p=0.02)
- 24% improvement in insulin sensitivity (hyperinsulinemic-euglycemic clamp)
4.2 Cardiovascular Safety Study (2018)
Meta-analysis of 12 trials (n=4,562) confirmed:
- CV risk ratio 0.91 (95% CI 0.82-1.01)
- GI bleeding incidence 1.2/100 patient-years
5. Procurement & Quality Assurance
5.1 Global Supply Chain
Available in multiple packaging formats:
| Package Size | Price Range (USD) | Lead Time |
|---|---|---|
| 25g | $60-100 | 2-5 days |
| 1kg | $1,800-2,200 | 4-6 weeks |
5.2 Technical Support
Contact our pharmaceutical experts:
Email: info@vivalr.com
Tel: (86) 15866781826
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