Sodium Phosphate Dibasic Dihydrate (CAS 10028-24-7): Technical Guide & Procurement Insights
Table of Contents
- 1. Product Specifications & Comparative Analysis
- 2. Industrial Applications & Functional Properties
- 3. Operational Guidelines & Safety Protocols
- 4. Case Studies: Real-World Implementations
- 5. Supplier Evaluation & Procurement Strategy
- 6. Technical Consultation & Custom Solutions
1. Product Specifications & Comparative Analysis
| Parameter | Specification |
|---|---|
| CAS Number | 10028-24-7 |
| Molecular Formula | Na₂HPO₄·2H₂O |
| Purity Grade | ACS/USP/Technical (99.0-101.5%) |
| pH (1% Solution) | 8.5-9.5 |
| Loss on Drying | ≤20.5% |
Comparative Analysis with Phosphate Derivatives
| Property | Dibasic Dihydrate | Monobasic | Tribasic |
|---|---|---|---|
| Buffer Range | pH 7.2-7.6 | pH 5.8-8.0 | pH 11.0-12.0 |
| Solubility (g/100ml H₂O) | 7.7 @ 20°C | 56.5 @ 20°C | 5.8 @ 20°C |
2. Industrial Applications & Functional Properties
Pharmaceutical Manufacturing
• Buffer agent in parenteral solutions (USP-grade compliance)
• Tablet disintegrant in oral dosage forms
• Calcium chelator in anticoagulant formulations
Food Technology Applications
• pH regulator in processed cheese (0.3-0.5% w/w)
• Emulsification aid in meat products
• Mineral fortification in nutritional supplements
3. Operational Guidelines & Safety Protocols
Material Handling Best Practices
• PPE Requirements: NIOSH-approved N95 respirator, chemical-resistant gloves
• Dust Control: Local exhaust ventilation (LEV) with ≥100 CFM airflow
• Spill Management: Neutralize with weak acetic acid solution
4. Case Studies: Real-World Implementations
Case Study 1: Vaccine Production Buffer Optimization
Client: European Biopharma Manufacturer
Challenge: Maintain pH stability in heat-sensitive mRNA vaccines
Solution: Custom anhydrous/dihydrate blend achieving ±0.05 pH variance
Outcome: 22% increase in vaccine thermal stability
Case Study 2: Dairy Processing Line Upgrade
Client: ASEAN Dairy Conglomerate
Challenge: Prevent calcium sedimentation in UHT milk
Solution: 0.45% dibasic phosphate + citrate synergy system
Outcome: Extended shelf-life to 180 days with 98% colloidal stability
5. Supplier Evaluation & Procurement Strategy
| Criterion | Evaluation Metrics |
|---|---|
| GMP Compliance | 21 CFR 210/211, ICH Q7 |
| Batch Traceability | ISO 9001:2015 documentation |
6. Technical Consultation & Custom Solutions
Contact our phosphate specialists:
Email: info@vivalr.com
Phone: (86) 15866781826
Request: Custom particle size distributions (10-500μm), cGMP certification support, or bulk API integration services.
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