Chenodeoxycholic Acid (CAS 474-25-9): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Chenodeoxycholic Acid (CDCA, CAS 474-25-9) is a primary bile acid synthesized from cholesterol in the liver. As a pharmaceutical-grade compound, it meets USP/EP standards for critical therapeutic and research applications.
| Parameter | Specification |
|---|---|
| CAS Number | 474-25-9 |
| Molecular Formula | C24H40O4 |
| Purity | ≥98% (HPLC) |
| Melting Point | 165-168°C |
| Solubility | Ethanol (50 mg/mL), DMSO (25 mg/mL) |
2. Key Applications & Use Cases
2.1 Therapeutic Applications
- Dissolution of cholesterol gallstones
- Treatment of cerebrotendinous xanthomatosis (CTX)
- Modulation of FXR nuclear receptors
2.2 Research Applications
- Studying bile acid metabolism pathways
- Investigation of apoptosis mechanisms
- Membrane permeability studies
3. Performance Comparison
| Property | CDCA | Cholic Acid | UDCA |
|---|---|---|---|
| Hydrophobicity Index | 0.89 | 0.65 | 0.72 |
| FXR Activation | High | Moderate | Low |
| Therapeutic Dose Range | 10-15 mg/kg/day | N/A | 8-12 mg/kg/day |
4. Industry-Specific Usage Scenarios
4.1 Pharmaceutical Manufacturing
Used as active ingredient in enteric-coated tablets for sustained release formulations.
4.2 Cell Culture Systems
Optimal concentration range: 50-100 μM for hepatocyte studies.
5. Client Success Stories
Case 1: European Pharma Innovator
Developed CTX treatment protocol using CDCA with 92% reduction in cholestanol levels.
Case 2: US Biotech Startup
Utilized CDCA in novel NASH drug development, achieving 40% FXR activation improvement.
6. Request Customized Solutions
Contact our technical team for formulation support or bulk orders:
Email: info@vivalr.com
Phone: (86) 15866781826
相关产品
Chemical Name: D-PANTOTHENIC ACID
CAS No.: 79-83-4
Molecular Formula: C9H17NO5
Molecular Weight: 219.24
Appearance: Colorless or Light Yellow Oily Liquid
Chemical Name: Dehydrocholic acid
Synonyms: Acide dehydrocholique; Triketocholanic acid
CAS No.: 81-23-2
Molecular Formula: C24H34O5
Molecular Weight: 402.53
Appearance: Powder
Chemical Name: Marbofloxacin
CAS No.: 115550-35-1
Molecular Formula: C17H19FN4O4
Molecular Weight: 362.36
Appearance: Red-Brown Crystal
Chemical Name: Oxirane, methyl-, polymer with oxirane, dodecyl ether
Cas No.: 68238-81-3
Molecular Fomula: C17H36O3
Molecular Weight: 288.46594
Chemical Name: Ammonium Iron(II) Sulfate
Synonyms: Diammonium iron bis(sulphate); iron (ii) ammonium sulfate
CAS No.: 10045-89-3
Molecular Formula: FeH5NO4S
Molecular Weight: 170.95
Chemical Name: 3-Chloroaniline
Synonyms: 1-Amino-3-chlorobenzene; m-Aminochlorobenzene; 3-Chlorobenzenamine; 3-Chlorophenylamine
CAS No.: 108-42-9
Molecular Formula: C6H6ClN
Molecular Weight: 127.57
Appearance: Colorless Liquid
Common English name: 5-iodo-2,3-dihydropyridazin-3-one
CAS No.: 825633-94-1
Molecular formula: C4H3IN2O
Molecular weight: 221.98
Sample: Available
Chemical Name: Tribehenin
Cas No.: 18641-57-1
Molecular Fomula: C69H134O6
Molecular Weight: 1059.8
Appearance: White waxy powder or solid
Chemical Name: N-(3-Aminopropyl)morpholine
CAS No.: 123-00-2
Molecular Formula: C7H16N2O
Molecular Weight: 144.21
Appearance: Colorless transparent liquid
Chemical Name: Di-n-amyl disulfide
Cas No.: 112-51-6
Molecular Fomula: C10H22S2
Molecular Weight: 206.41
Chemical Name: DL-4-Chlorophenylglycine
Cas No.: 6212-33-5
Molecular Fomula: C8H8ClNO2
Molecular Weight: 185.61
评论
目前还没有评论。