1. Product Overview & Specifications

Chemical Name: (R)-(+)-2-Methyl-2-propanesulfinamide
CAS: 196929-78-9
Molecular Formula: C₄H₁₁NOS
Molecular Weight: 121.20 g/mol

Physical Properties

Supplier Comparison

2. Key Applications

• Chiral Auxiliary: Critical for asymmetric synthesis of amines via sulfinamide intermediates.
• Pharmaceutical Intermediates: Used in API synthesis for antihypertensive and antiviral drugs.
• Catalysis: Serves as a ligand in iridium-catalyzed asymmetric hydrogenation of olefins.
• Organocatalysis: Enantioselective reduction of ketimines in multistep syntheses.

3. Usage Scenarios

Case 1: Synthesis of Chiral β-Chloro Sulfinamides

Reaction of (R)-(+)-2-Methyl-2-propanesulfinamide with aldehydes/ketones forms P,N-sulfinyl imine ligands. These intermediates enable >95% enantiomeric excess (ee) in hydrogenation reactions.

Case 2: Preparation of Enantioenriched Aziridines

Used in Staudinger reactions with triphenylphosphine to generate chiral nitrogen-containing heterocycles for antibiotic development.

4. Client Case Studies

Case Study A: Shanghai Yuanye Bio-Technology

Application: Supplied 25kg batches for a pharmaceutical client synthesizing HCV protease inhibitors.
Result: Achieved 99.2% purity and consistent chiral integrity across 10 production cycles.

Case Study B: Suzhou Amateks Biotech

Application: Custom synthesis of sulfinamide derivatives for agrochemical research.
Result: Reduced reaction time by 40% compared to traditional methods.

5. Contact for Technical Support

For bulk orders, custom synthesis, or technical documentation:
Email: info@vivalr.com
Phone: (86) 15866781826