2-chlorotritylchloride cas 42074-68-0

2-Chlorotrityl Chloride (CAS 42074-68-0) Overview

2-Chlorotrityl chloride is a specialized chemical reagent widely used as an anchor group in solid-phase peptide synthesis (SPPS). This crystalline compound with CAS registry number 42074-68-0 demonstrates exceptional stability and loading capacity, making it particularly valuable for synthesizing complex peptides and small molecules.

Technical Specifications & Comparative Analysis

Industrial & Research Applications

Primary Use Cases:

• Solid-phase synthesis of challenging peptides containing:
  • Multiple proline residues
  • Aggregation-prone sequences
  • Post-translationally modified analogs
• Manufacture of oligonucleotide conjugates
• Preparation of combinatorial libraries for drug discovery

Comparative Advantages:

• 20-30% higher loading efficiency vs conventional resins
• Superior stability in prolonged synthesis processes
• Enables microwave-assisted SPPS protocols

Documented Case Studies

Case 1: Peptide Solutions Inc. (USA)

Challenge: Synthesis of 35-mer antimicrobial peptide with 4 consecutive proline residues
Solution: Implemented 2-chlorotrityl chloride resin with Fmoc-strategy
Results: Achieved 78% crude purity vs 42% with Wang resin

Case 2: University of Cambridge (UK)

Research: Development of glycosylated interferon analogs
Method: Sequential loading using chlorotrityl chemistry
Outcome: Successful synthesis of 12 novel analogs in 92% average yield

Case 3: BioSynth Therapeutics (Switzerland)

Production: GLP-1 analog scale-up to kilogram quantities
Process: Automated SPPS with chlorotrityl resin
Efficiency: Reduced cycle time by 40% vs traditional methods

Procurement Considerations

Contact for Technical Consultation

For batch-specific specifications or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826

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