1. Product Overview & Specifications

Gambogenic Acid (CAS 173932-75-7) is a bioactive compound derived from Garcinia hanburyi, widely used in pharmaceutical research. Key specifications include:

Supplier Comparison

2. Applications & Pharmacological Research

Gambogenic Acid demonstrates significant antitumor activity through:

• Inhibition of ovarian cancer A2780 cell proliferation via mitochondrial apoptosis pathways
• Synergistic effects with Adriamycin in breast cancer MCF-7 cell apoptosis (JNK signaling modulation)
• Dose-dependent suppression of HeLa cell migration and metastasis

Primary Research Uses:

• Anticancer drug discovery
• Apoptosis mechanism studies
• Phytochemical reference standard

3. Usage Guidelines

Sample Preparation:

1. Reconstitute in DMSO at 10mM concentration
2. Aliquot and store at -20°C (2-week stability)
3. Avoid repeated freeze-thaw cycles

Experimental Protocols:

• Cell viability assays: 0.1-10μM concentration range
• Apoptosis analysis: 24-48hr exposure periods

4. Case Studies

Study 1: Shanghai Institute of Materia Medica (2023)
– Achieved 72% inhibition of HeLa cell migration at 5μM concentration
– Identified MMP-9 downregulation as key mechanism

Study 2: National Cancer Center (2024)
– Demonstrated 1.8-fold apoptosis enhancement in combination with paclitaxel
– Reduced IC₅₀ from 12nM to 6nM in ovarian cancer models

5. Client Success Stories

Client A: Biopharmaceutical Startup (Shenzhen)
– Integrated Gambogenic Acid into high-throughput screening platform
– Identified 3 novel lead compounds in 6-month period

Client B: University Research Lab (Boston)
– Published Nature Communications paper on dual-targeting therapy
– Cited consistent HPLC purity (98.2-98.7% across 15 batches)

6. Request Quotation

Contact our technical team for:

• Bulk pricing (1g+ quantities)
• Custom purity specifications (up to 99.5%)
• GMP-grade manufacturing options

Contact Information:
Email: info@vivalr.com
Tel: (86) 15866781826